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|Tested species reactivity||Dog, Human, Pig|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Raji Burkitt's lymphoma cell line.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2 ug/ml|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 2 publications below|
This antibody will not cross-react with mouse.
CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Entry of human cytomegalovirus into porcine endothelial cells depends on both the cellular vascular origin and the viral strain.
MA1-19105 was used in flow cytometry to study the effect of vascular origin and viral strain on the mechanisms used by human CMV to enter porcine endothelial cells
|Taveira A,Ponroy N,Mueller NJ,Millard AL||Xenotransplantation (21:324)||2014|
BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
MA1-19105 was used in flow cytometry to show that BRAG2 acts at clathrin-coated pits to promote integrin internalization by activating Arf5
|Moravec R,Conger KK,D'Souza R,Allison AB,Casanova JE||The Journal of biological chemistry (287:31138)||2012|
CD29; fibronectin receptor subunit beta; FNRB; glycoprotein IIa; GPIIA; integrin beta 1; integrin beta-1; integrin beta-1 subunit; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITGB1; MDF2; MSK12; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLA-BETA; VLAB
CD29; FNRB; GPIIA; ITGB1; MDF2; MSK12; VLA-BETA; VLAB