|Tested species reactivity||Dog, Human, Pig|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Raji Burkitt's lymphoma cell line.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody will not cross-react with mouse.
CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Entry of human cytomegalovirus into porcine endothelial cells depends on both the cellular vascular origin and the viral strain.
MA1-19762 was used in flow cytometry to study the effect of vascular origin and viral strain on the mechanisms used by human CMV to enter porcine endothelial cells
|Taveira A,Ponroy N,Mueller NJ,Millard AL||Xenotransplantation (21:324)||2014|
|Not Applicable||Not Cited||
A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs.
MA1-19762 was used in flow cytometry to characterize human mesenchymal stromal cells from different sources
|Campioni D,Rizzo R,Stignani M,Melchiorri L,Ferrari L,Moretti S,Russo A,Bagnara GP,Bonsi L,Alviano F,Lanzoni G,Cuneo A,Baricordi OR,Lanza F||Cytometry. Part B, Clinical cytometry (76:225)||2009|
|Not Applicable||Not Cited||
Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment.
MA1-19762 was used in flow cytometry to use flow cytometry to characterize mesenchymal stromal cell subsets and abnormalities
|Campioni D,Moretti S,Ferrari L,Punturieri M,Castoldi GL,Lanza F||Haematologica (91:364)||2006|
Susceptibility of human placenta derived mesenchymal stromal/stem cells to human herpesviruses infection.
MA1-19762 was used in flow cytometry to assess the susceptibility of fetal membranes-derived mesenchymal stromal/stem cells to all members of the human Herpesviridae family.
|Avanzi S,Leoni V,Rotola A,Alviano F,Solimando L,Lanzoni G,Bonsi L,Di Luca D,Marchionni C,Alvisi G,Ripalti A||PloS one (8:null)||2013|