|Tested species reactivity||Mouse, Rat|
|Published species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG|
|Storage buffer||PBS with 10% sucrose, 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 2 publications below|
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.
MCD6105 was used in flow cytometry to investigate the contribution of BECN1 to breast cancer.
|Cicchini M,Chakrabarti R,Kongara S,Price S,Nahar R,Lozy F,Zhong H,Vazquez A,Kang Y,Karantza V||Autophagy (10:2036)||2014|
p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity.
MCD6105 was used in flow cytometry to study the roles of p130Cas and c-Kit in mammary epithelial cell differentiation and the significance for the development of basal-like breast cancer.
|Tornillo G,Elia AR,Castellano I,Spadaro M,Bernabei P,Bisaro B,Camacho-Leal Mdel P,Pincini A,Provero P,Sapino A,Turco E,Defilippi P,Cabodi S||Stem cells (Dayton, Ohio) (31:1422)||2013|