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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified recombinant human interferon-gamma (IFN-gamma).|
|Storage buffer||PBS, pH 7.5|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This product is recommended as a capture antibody in Sandwich ELISA applications.
IFN gamma, also called Type II interferon, macrophage activation factor, and immune interferon is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE it appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific and includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFNg is involved in cytokine regulation and also acts synergistically with other cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Antipsychotic drugs suppress the AKT/NF-κB pathway and regulate the differentiation of T-cell subsets.
AHC4432 was used in blocking assay to examine how antipsychotic drugs affect immune responses.
|Chen ML,Tsai TC,Lin YY,Tsai YM,Wang LK,Lee MC,Tsai FM||Immunology letters (140:81)||2011|
|Human||Not Cited||A novel ELISPOT assay to enhance detection of antigen-specific T cells employing antigen-presenting cells expressing vector-driven human B7-1.||Arlen PM,Gulley JL,Palena C,Marshall J,Schlom J,Tsang KY||Journal of immunological methods (279:183)||2003|
|Human||Not Cited||Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses.||Mascart F,Verscheure V,Malfroot A,Hainaut M,Piérard D,Temerman S,Peltier A,Debrie AS,Levy J,Del Giudice G,Locht C||Journal of immunology (Baltimore, Md. : 1950) (170:1504)||2003|
|Mouse||Not Cited||Biological characterization of lipopolysaccharide from Treponema pectinovorum.||Kesavalu L,Falk CW,Davis KJ,Steffen MJ,Xu X,Holt SC,Ebersole JL||Infection and immunity (70:211)||2002|
|Human||Not Cited||Cytokine responses to treponema pectinovorum and treponema denticola in human gingival fibroblasts.||Nixon CS,Steffen MJ,Ebersole JL||Infection and immunity (68:5284)||2000|
Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression.
AHC4432 was used in ELISA to show that cholera toxin inhibits the production of interleukin-2.
|Braun MC,He J,Wu CY,Kelsall BL||The Journal of experimental medicine (189:541)||1999|
|Human||Not Cited||Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.||Messmann RA,Ullmann CD,Lahusen T,Kalehua A,Wasfy J,Melillo G,Ding I,Headlee D,Figg WD,Sausville EA,Senderowicz AM||Clinical cancer research : an official journal of the American Association for Cancer Research (9:562)||2003|
IFN-gamma; IFN-y; IFNG; immune interferon; Interferon y; interferon, gamma
IFG; IFI; IFNG