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|Tested species reactivity||Human|
|Published species reactivity||Human, Rhesus monkey|
|Host / Isotype||Mouse / IgG1, kappa|
|Storage buffer||PBS with sucrose, 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
IFN gamma, also called Type II interferon, macrophage activation factor, and immune interferon is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE it appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific and includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFNg is involved in cytokine regulation and also acts synergistically with other cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory T cells.
MHCIFG05 was used in flow cytometry to study virus-specific human memory T-cell activation in response to Dribble-mediated cross-presentation of viral antigens.
|Ye W,Xing Y,Paustian C,van de Ven R,Moudgil T,Hilton TL,Fox BA,Urba WJ,Zhao W,Hu HM||Journal of translational medicine (12:null)||2014|
|Rhesus monkey||Not Cited||
CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.
MHCIFG05 was used in flow cytometry to investigate changes to macaque NK-cell subsets during infection with SIV
|Reeves RK,Gillis J,Wong FE,Yu Y,Connole M,Johnson RP||Blood (115:4439)||2010|
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
MHCIFG05 was used in flow cytometry to study T regulatory cells in inflamed human liver samples
|Oo YH,Weston CJ,Lalor PF,Curbishley SM,Withers DR,Reynolds GM,Shetty S,Harki J,Shaw JC,Eksteen B,Hubscher SG,Walker LS,Adams DH||Journal of immunology (Baltimore, Md. : 1950) (184:2886)||2010|
IFN-gamma; IFN-y; IFNG; Immune interferon; Interferon gamma; Interferon y; interferon, gamma
IFG; IFI; IFNG