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|Tested species reactivity||Fruit fly, Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||The full-length mouse JAB-1 gene expressed in E. coli.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay dependent|
|Immunohistochemistry (IHC)||Assay dependent|
|Immunoprecipitation (IP)||0.5-1 µg/ml|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-23244 detects Jab1 in Human, Rat, Drosophila, and Mouse samples.
MA1-23244 has been successfully used in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot procedures.
MA1-23244 immunogen corresponds to the full-length mouse JAB-1 gene expressed in E. coli..
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
38 kDa Mov34 homolog; COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2; MGC3149; MOV-34; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
AI303502; COPS5; CSN5; JAB1; Kic2; MOV-34; Mov34; SGN5