|Tested species reactivity||Fruit fly, Human, Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||The full-length mouse JAB-1 gene expressed in E. coli.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-23248 detects Jab1 in human and mouse samples.
MA1-23248 has been successfully used in immunoprecipitation and Western blot procedures.
The MA1-23248 immunogen is full-length, mouse JAB-1 gene expressed in E. coli.
JAB-1 is a 38a protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.