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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:6,000 | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:400 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Rat |
Published species |
Human |
Host/Isotype |
Mouse / IgG2b |
Class |
Monoclonal |
Type |
Antibody |
Clone |
3H7A8 |
Immunogen |
JAK1 Fusion Protein Ag17940 (8-363 aa encoded by BC132729) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: EDCNAMAFC AKMRSSKKTE VNLEAPEPGV EVIFYLSDRE PLRLGSGEYT AEELCIRAAQ ACRISPLCHN LFALYDENTK LWYAPNRTIT VDDKMSLRLH YRMRFYFTNW HGTNDNEQSV WRHSPKKQKN GYEKKKIPDA TPLLDASSLE YLFAQGQYDL VKCLAPIRDP KTEQDGHDIE NECLGMAVLA ISHYAMMKKM QLPELPKDIS YKRYIPETLN KSIRQRNLLT RMRINNVFKD FLKEFNNKTI CDSSVSTHDL KVKYLATLET LTKHYGAEIF ETSMLLISSE NEMNWFHSND GGNVLYYEVM VTGNLGIQWR HKPNVVSVEK EKNKLKRKKL ENKHKKDEEK NKIREEW (8-363 aa encoded by BC132729)
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.10.2; JAK-1; Janus kinase 1; Janus protein tyrosine kinase 1; kinase Jak1; Tyrosine-protein kinase JAK1
Gene Aliases: JAK1; JAK1A; JAK1B; JTK3
UniProt ID: (Human) P23458
Entrez Gene ID: (Human) 3716, (Rat) 84598
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