The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
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Protein Aliases: C jun amino terminal kinase interacting protein 2; C-Jun-amino-terminal kinase-interacting protein 2; Homologous to mouse JIP 1; homologous to mouse JIP-1; IB 2; IB-2; IB2; Islet brain 2; islet-brain 2; Islet-brain-2; JIP 2; JIP-2; JIP2; JNK interacting protein 2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; MAPK8IP2; Mitogen activated protein kinase 8 interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2; PRKM8 interacting protein like; PRKM8IPL
Gene Aliases: 3230402N03Rik; AI847694; AW049958; IB-2; IB2; JIP2; MAPK8IP2; PRKM8IPL; R75148