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JunD is a transcription factor which is coded by JunD gene. JunD transcriptional activity is modulated by phosphorylation in response to cellular stress via the c-Jun N terminal kinase (JNK)/Stress-Activated Protein Kinase (SAPK) family of protein kinase. Jun proteins are capable of forming dimers with Fos, ATF and CREB family transcription factors to form the AP-1 complex that differentially regulates a variety of target genes involved in cellular growth, proliferation, differentiation and apoptosis. Also, JunD plays an important role in metabolism via modulation of IGF-1 signaling pathway.
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Protein Aliases: activator protein 1; JUN D; jun D proto-oncogene; JunD-FL isoform; Oncogene Jun-D; Transcription factor AP-1 subunit JunD; Transcription factor JunD
Gene Aliases: AP-1; JUND
UniProt ID: (Human) P17535
Entrez Gene ID: (Human) 3727
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