MA1-06305 detects K-cadherin in human and rat samples.
MA1-06305 has sucessfully been used in Western blotting, immunocytochemistry, and immunohistochemistry (paraffin). By Western blotting, it detects a ~120 kDa protein representing K-cadherin.
The MA1-06305 immunogen is affinity purified extracellular domain of human cadherin-6-GST fusion protein.
Store at 4°C or in small aliquots at -20°C.
Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 6, type 2, K-cadherin (fetal kidney); Cadherin-6; K-cadherin; Kidney Cadherin
Gene Aliases: CAD6; CDH6; KCAD
Molecular Function: cadherin