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KCNIP2 Antibody (TA807376S) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KCNIP2 (RC203823, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-KCNIP. Positive lysates LY406638 (100 µg) and LC406638 (20 µg) can be purchased separately from OriGene.
Product Details
TA807376S
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2G8
Immunogen
Full length human recombinant protein of human KCNIP2 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP2; KChlP2; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; Potassium channel-interacting protein 2
Gene Aliases: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61
Entrez Gene ID: (Human) 30819
detection of calcium ion
potassium ion transport
muscle contraction
signal transduction
chemical synaptic transmission
regulation of heart contraction
clustering of voltage-gated potassium channels
cardiac conduction
potassium ion export
potassium ion transmembrane transport
membrane repolarization
regulation of potassium ion transmembrane transport
regulation of cation channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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