Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2P K ion channel TRESK; Potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; tandem-pore K+ (K(2P)) channel; Tresk-2; TWIK-related individual K+ channel; TWIK-related spinal cord K+ channel; Two-pore-domain potassium channel TRESK
Gene Aliases: Gm781; Kcnk18; Tresk; Tresk-2; Tresk2; Trik