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KCNK3 Antibody (MA5-45701) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with TASK1 Potassium Channel monoclonal antibody (Product # MA5-45701) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 60 min RT, 5 min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Re... View More
Product Details
MA5-45701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
S374-48
Immunogen
Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1.
Conjugate
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
47.35mM phosphate/2.15mM MES, pH 7.4, with 1.033mM EDTA
Contains
no preservative
Storage conditions
4° C
Product Specific Information
Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3.
Target Information
KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acid-sensitive potassium channel protein TASK; Acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; Cardiac two pore background K(+) channel; cTBAK 1; cTBAK-1; KCNK9; Potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; TASK 1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two P domain potassium channel; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
Gene Aliases: Ctbak; cTBAK-1; K2p3.1; KCNK3; OAT1; PPH4; rTASK; TASK; TASK-1; TASK1; TBAK1
UniProt ID: (Human) O14649, (Rat) O54912, (Mouse) O35163
Entrez Gene ID: (Human) 3777, (Rat) 29553, (Mouse) 16527
Molecular Function:
ion channel
transporter
potassium ion transport
chemical synaptic transmission
brain development
stabilization of membrane potential
ion transmembrane transport
response to drug
negative regulation of cytosolic calcium ion concentration
cardiac conduction
cellular response to zinc ion
cellular response to hypoxia
potassium ion transmembrane transport
cochlea development
mitophagy in response to mitochondrial depolarization
regulation of ion transmembrane transport
transport
ion transport
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