FIGURE: 1 / 3
Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3.
KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
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Protein Aliases: acid-sensitive potassium channel protein TASK; Acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; Cardiac two pore background K(+) channel; cTBAK 1; cTBAK-1; KCNK9; Potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; TASK 1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two P domain potassium channel; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
Gene Aliases: Ctbak; cTBAK-1; K2p3.1; KCNK3; OAT1; PPH4; rTASK; TASK; TASK-1; TASK1; TBAK1