Kcnt2 calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. KCa channels are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance). Kcnt2 is an outward rectifying potassium channel, and produces rapidly activating outward rectifier K(+) currents. Kcnt2 is activated by high intracellular sodium and chloride levels. Further, Kcnt2 channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. Functionally, Kcnt2 is inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.
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Protein Aliases: KCa4.2; KCNT2; Potassium channel subfamily T member 2; potassium channel, sodium activated subfamily T, member 2; potassium channel, subfamily T, member 2; Sequence like an intermediate conductance potassium channel subunit; SLICK; Slo2.1; sodium and chloride activated ATP sensitive potassium channel Slo2.1; Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1; sodium- and chloride-activated ATP-sensitive potassium channel; sodium- and chloride-activated ATP-sensitive potassium channel subunit; sodium-and chloride-activated ATP-sensitive potassium channel (SLICK)
Gene Aliases: E330038N15Rik; KCa4.2; KCNT2; SLICK; SLO2.1