QED Bioscience

KDEL Receptor Monoclonal Antibody (KR-10)

Name: KDEL Receptor Monoclonal Antibody (KR-10)
Brand: QED Bioscience
SKU: 11078-100UG

View all (22) KDEL antibodies

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Datasheet

Certificates

Protocols

Questions & Answers

Datasheet

Certificates

Protocols

Questions & Answers

Additional Information:

Antibody Testing Data (2)

KDEL Receptor Antibody in Immunocytochemistry (ICC/IF)

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KDEL Receptor Antibody (11078-100UG) in ICC/IF

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-KDEL Receptor Monoclonal Antibody, Clone KR-10 (11078). Tissue: NRK cells. Species: Rat. Primary Antibody: Mouse Anti-KDEL Receptor Monoclonal Antibody (11078) at 1:1000. Secondary Antibody: APC Goat Anti-Mouse (red). Counterstain: DAPI (blue) nuclear stain. KR-10 staining red; DAPI staining blue. Merged images. Courtesy of: Institute of Mol. ... View More

KDEL Receptor Antibody in Western Blot (WB)

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Immunogen image

Immunogen Image KDEL Receptor Monoclonal Antibody (KR-10)

Product Details

11078-100UG

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

Immunocytochemistry (ICC/IF)

1:1,000

Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Fruit fly, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat, Xenopus

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

KR-10

Immunogen

Peptide corresponding to aa 192-212 of bovine KDEL receptor

3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 108K heat shock protein; 108K HSP; 78 kDa glucose-regulated protein; 78-kD glucose-regulated protein precursor; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250|UniProtKB:P08113}; 98 kDa protein kinase; Binding-immunoglobulin protein; BiP; BiP protein; CG5183-PA; CG5183-PB; CG5183-PC; chaperone; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250|UniProtKB:P08113}; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; ER lumen protein retaining receptor 1; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor; ER lumen protein-retaining receptor 1; ERp99; glucose regulated protein, 78 kDa; glucose-regulated protein; glucose-regulated protein (grp78); glucose-regulated protein GRP94; glucose-regulated protein, 78kDa; gp96 homolog; GRP 78; GRP-78; GRP-94; GRP94; Heat shock 108 kDa protein; heat shock 70 kDa protein 5; heat shock 70 kDa protein 5a; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 108; heat shock protein 108.; heat shock protein 5; Heat shock protein 70 family protein 5; Heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250|UniProtKB:P08113}; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta, member 1; Heat shock protein family A member 5; Heat shock protein family C member 4; heavy-chain binding protein BiP; HSP 108; hsp108; hsp70; HSP70 family protein 5; HSP90 beta; hsp90b1 {ECO:0000250|UniProtKB:P08113}; immunoglobulin binding protein; Immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; KDEL receptor-like protein; KDEL-receptor; KdelR-PA; KdelR-PB; KdelR-PC; lethal (2) 31Em; Lys-Asp-Glu-Leu; Polymorphic tumor rejection antigen 1; PPK 98; Putative MAPK-activating protein PM23; RP23-446N16.1; Steroidogenesis-activator polypeptide; stress-inducible tumor rejection antigen gp96; Transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen gp96; unnamed protein product; XAP-1 antigen

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Gene Aliases: 8030486F04Rik; AL022860; AU019543; AW215843; baffled; BEST:CK00230; BIP; BiP/Grp78; CG5183; CK00230; D2Wsu141e; D2Wsu17e; Dmel\CG5183; Dmel_CG5183; dmErd2; ECGP; endoplasmin; ERD2; ERD2.1; ERp99; GP96; GRP78; GRP94; HDEL; HEL-S-125m; HEL-S-89n; HEL35; Hsce70; hsp108; HSP90B1; HSPA5; hspa5a; HSPC4; I79_019946; I79_020931; KDELR; KDELR1; l(2)31Em; l(2)k00311; mBiP; PM23; ppk98; SEZ-7; Sez7; TA-3; Targ2; Tra-1; TRA1; XAP-1; XELAEV_180384511mg

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Function(s)

ATP binding nucleotide binding RNA binding protein phosphatase inhibitor activity calcium ion binding protein binding hydrolase activity ATPase activity protein phosphatase binding protein binding involved in protein folding low-density lipoprotein particle receptor binding unfolded protein binding ATP-dependent protein folding chaperone heat shock protein binding misfolded protein binding enzyme binding protein domain specific binding protein serine/threonine kinase inhibitor activity ubiquitin protein ligase binding ribosome binding cadherin binding chaperone binding virion binding glycoprotein binding KDEL sequence binding ER retention sequence binding molecular_function Hsp90 family chaperone membrane trafficking regulatory protein

Process(es)

ER-associated ubiquitin-dependent protein catabolic process response to hypoxia protein folding protein transport positive regulation of Wnt signaling pathway retrograde protein transport, ER to cytosol actin rod assembly positive regulation of toll-like receptor signaling pathway protein folding in endoplasmic reticulum response to endoplasmic reticulum stress ERAD pathway negative regulation of apoptotic process sequestering of calcium ion cellular response to manganese ion cellular response to ATP protein localization to plasma membrane regulation of phosphoprotein phosphatase activity intracellular sequestering of iron ion response to unfolded protein endoplasmic reticulum unfolded protein response negative regulation of protein complex assembly cellular response to unfolded protein protein refolding chaperone mediated protein folding requiring cofactor negative regulation of IRE1-mediated unfolded protein response positive regulation of cell migration posttranslational protein targeting to membrane, translocation maintenance of protein localization in endoplasmic reticulum translational initiation ER overload response cerebellum structural organization cerebellar Purkinje cell layer development substantia nigra development negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein ubiquitination IRE1-mediated unfolded protein response PERK-mediated unfolded protein response cellular response to glucose starvation positive regulation of transcription from RNA polymerase II promoter proteolysis involved in cellular protein catabolic process regulation of protein folding in endoplasmic reticulum cellular response to interleukin-4 regulation of ATF6-mediated unfolded protein response regulation of IRE1-mediated unfolded protein response regulation of PERK-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response toxin transport response to stress activation of signaling protein activity involved in unfolded protein response positive regulation of embryonic development cellular response to antibiotic T cell cytokine production retrograde vesicle-mediated transport, Golgi to ER T cell differentiation T cell apoptotic process protein retention in ER lumen vesicle-mediated transport ER to Golgi vesicle-mediated transport transport biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KDEL Receptor Monoclonal Antibody (KR-10)

KDEL Receptor Antibody (11078-100UG) in ICC/IF

Product Details

11078-100UG

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Amount

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

References (0)

Bioinformatics

Performance Guarantee

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