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Immunogen sequence: PQEAQKLAAE RARAPVVPYG VDLHYWGQEL PTAGKIVKSD SQHRFWKPSE VEEEVVNADI SEMLRSRHIT FAGKFEPVQH WCRAPRPDGR LCERQDRLK
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.
The protein encoded by KIAA1530 appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex, and is thought to be involved in the transcription-coupled nucleotide excision repair (TC-NER) pathway to help remove lesions in the DNA that block transcription. Defects in KIAA1530 can cause UV-sensitive syndrome 3. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: UV-stimulated scaffold protein A
Gene Aliases: KIAA1530; UVSS3; UVSSA
UniProt ID: (Human) Q2YD98
Entrez Gene ID: (Human) 57654
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