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Product Details
A301-070A
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000-1:10,000 | - |
Immunoprecipitation (IP) |
2-5 µg/mg lysate | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Between 900 and 950 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
0.20 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
TBS, pH 7.0 to 8.0, with 0.1% BSA |
Contains |
0.09% sodium azide |
Storage conditions |
4° C |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis. KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle. Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Kinesin-like protein KIF1C; spastic ataxia 2 (autosomal recessive)
Gene Aliases: KIAA0706; KIF1C; LTXS1; SATX2; SAX2; SPAX2; SPG58
UniProt ID: (Human) O43896
Entrez Gene ID: (Human) 10749
Molecular Function:
microtubule binding motor protein
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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