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Search Thermo Fisher Scientific
Sequence of this protein is as follows: PGEQSLPCTE RKPAATARLS RRGTSLSPPP ESSGSPQQPG LSAPHSRQIP APQGAVLVQR EKDLPNYNWN SFGLRFGKRE AAPGNHGRSA GRGWGAGAGQ
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Kisspeptin-1; malignant melanoma metastasis-suppressor; Metastasis-suppressor KiSS-1; metastin; prepro-kisspeptin
Gene Aliases: HH13; KiSS-1; KISS1; PP5098
UniProt ID: (Human) Q15726
Entrez Gene ID: (Human) 3814
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