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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human KLF10/11|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
early growth response-alpha; FKLF; FKLF1; GDNF-inducible factor; klf11; Krueppel-like factor 10; Krueppel-like factor 11; Kruppel-like factor 10; Kruppel-like factor 11; MODY7; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB inducible early growth response 2; TGFB inducible early growth response 3; TGFB-inducible early growth response protein 1; TGFB-inducible early growth response protein 2; TGFB-inducible early growth response protein 2b; TGFB-inducible early growth response protein 3; TIEG-1; TIEG-2; TIEG-3; TIEG2; Tieg3; transcription factor GIF; transforming growth factor-beta-inducible early growth response protein 1; transforming growth factor-beta-inducible early growth response protein 2; transforming growth factor-beta-inducible early growth response protein 3; zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
9830142A17; AI115143; Cpg20; D12Ertd427e; EGR-alpha; EGR[a]; EGRA; Egral; FKLF; FKLF1; Gdnfif; KLF10; KLF11; mGIF; MODY7; TIEG; TIEG-1; TIEG1; TIEG2; Tieg2b; Tieg3