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Invitrogen

KLF4 Monoclonal Antibody (CL5782)

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KLF4 Monoclonal Antibody (CL5782)

Product Details

MA5-35030

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500
-

Immunocytochemistry (ICC/IF)

2-10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

CL5782

Immunogen

Synthetic Peptide corresponding to Human KLF4
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.00 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2848935

Product Specific Information

Immunogen sequence: GREKTLRQAG APNNRWREE

Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 89%.

Target Information

Kruppel like factor 4 (KLF4) protein is encoded by the KLF4 gene located on chromosome 9 in humans. It is also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF) and belongs to a family of conserved Kruppel-like factor family of DNA binding zinc finger transcription factors. KLF4 exerts its functional relevance across varied cellular pathways. As one of the four Yamanaka factors, it plays a key role in reprogramming differentiated cells into pluripotent stem cells. Most studies have focused on its specific role in endothelial cell signaling, adipogenesis, differentiation, embryogenesis and cell cycle control. Localization plays an important role in the biological significance of this protein wherein nuclear localization is associated with its function as an oncogene and cytosolic localization with tumor suppression specific effect.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 4; Kruppel like factor 4; Kruppel-like factor 4 (gut); Kruppel-like zinc finger protein; RP11-150J11.1; transcription factor; unnamed protein product

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Gene Aliases: EZF; GKLF; KLF4

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UniProt ID: (Human) O43474

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Entrez Gene ID: (Human) 9314

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding zinc ion binding chromatin DNA binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter defense response to tumor cell transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter mesodermal cell fate determination negative regulation of cell proliferation epidermis development epidermal cell differentiation gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of muscle hyperplasia negative regulation of angiogenesis stem cell population maintenance negative regulation of cell migration epithelial cell differentiation post-embryonic camera-type eye development positive regulation of telomere maintenance response to retinoic acid negative regulation of interleukin-8 production negative regulation of heterotypic cell-cell adhesion somatic stem cell population maintenance post-embryonic hemopoiesis regulation of cell proliferation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of nitric oxide biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration epidermis morphogenesis negative regulation of inflammatory response positive regulation of protein metabolic process negative regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of response to cytokine stimulus establishment of skin barrier cellular response to hydrogen peroxide negative regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to growth factor stimulus cellular response to laminar fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis regulation of blastocyst development positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of sprouting angiogenesis negative regulation of leukocyte adhesion to arterial endothelial cell cellular response to leukemia inhibitory factor cellular response to endothelin negative regulation of G1/S transition of mitotic cell cycle negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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