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MA5-15700 targets KLHL1 in indirect ELISA, IF and WB applications and shows reactivity with Human, Mouse and Rat samples.
The MA5-15700 immunogen is purified recombinant fragment of human KLHL1 expressed in E. Coli.
MA5-15700 detects KLHL1 which has a predicted molecular weight of approximately 82kDa. In Western blot, MA5-15700 did not detect KLHL1 in whole rat brain lysates, but detected KLHL1 in hippocampal neuronal cell lysates.
The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins. Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ30047; kelch-l like; kelch-like 1; kelch-like family member 1; Kelch-like protein 1; Mayven-related protein 2; RP11-394C23.1
Gene Aliases: KIAA1490; KLHL1; mKIAA1490; MRP2
Molecular Function: scaffold/adaptor protein