Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
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Protein Aliases: H NRPN; hK8; Kallikrein-8; kallikrein-related peptidase 8; Kallikrein8; Neuropsin; NP; Ovasin; PRO322; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; UNQ283
Gene Aliases: HNP; KLK8; NP; NRPN; PRSS19; TADG14; UNQ283/PRO322
UniProt ID: (Human) O60259
Entrez Gene ID: (Human) 11202
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule