Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
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Protein Aliases: FLJ11249; importin alpha 7 subunit; Importin alpha-S2; Importin subunit alpha-7; importin-alpha-S2; karyopherin (importin) alpha 5; karyopherin (importin) alpha 6; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); Karyopherin subunit alpha-6; MGC17918; RP4-622L5.1
Gene Aliases: IPOA7; Kpna5; KPNA6; KPNA7; NPI-2
Molecular Function: transporter