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|Tested species reactivity||Virus|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-14769 targets KSHV ORF45 in IHC and WB applications and shows reactivity with Virus samples.
The MA5-14769 immunogen is purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi"e;s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman"e;s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Kaposi's sarcoma-associated herpesvirus