KSK 003-01-02 reacts with free as well as MHC class I associated b2-microglobulin from the genus Caiman.
KSK 003-01-02 has been successfully used in immunohistochemistry and Western blotting techniques. KSK 003-01-02 is suitable for Western blotting, flow cytometry, immunoprecipitation, and affinity purification on caiman b2-microglobulin.
The KSK 003-01-02 immunogen recombinant caiman b2-microglobulin.
KSK 003-01-02 reacts with a non-polymorphic epitope on caiman b2-microglobulin.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-F; B2-microglobulin; Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m