Invitrogen

KV1.1 (KCNA1) Recombinant Rabbit Monoclonal Antibody (SN66-06)

View all (16) KV1.1 (KCNA1) antibodies

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Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (2)

KV1.1 (KCNA1) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 2

KV1.1 (KCNA1) Antibody (MA5-32317) in IHC (P)

Immunohistochemical analysis of KV1.1 (KCNA1) of paraffin-embedded rat brain tissue using a KV11-KCNA1 Monoclonal antibody (Product #MA5-32317). Counter stained with hematoxylin.

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KV1.1 (KCNA1) Antibody in Western Blot (WB) — Western blot analysis of KV1.1 (KCNA1) in human brain lysate using a KV1.1 (KCNA1) Monoclonal antibody (Product # MA5-32317) at a dilution of 1:1,000.

Product Details

MA5-32317

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:5,000

Immunohistochemistry (IHC)

1:50-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SN66-06

Immunogen

Synthetic peptide within Human KCNA1 aa 491-440

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2809599

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments, and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif. The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain potassium channel protein-1; IA; MBK1; megencephaly; MGC126782; MGC138385; MKI; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; potassium voltage gated channel, shaker related subfamily, member 1; Potassium voltage-gated channel subfamily A member 1; potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); RBKI; RCK1; Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1

Gene Aliases: AEMK; AI840627; EA1; HBK1; HUK1; Kca1-1; Kcna; KCNA1; Kcpvd; KV1.1; MBK1; mceph; Mk-1; MK1; RBK1; Shak

UniProt ID: (Human) Q09470, (Mouse) P16388, (Rat) P10499

Entrez Gene ID: (Human) 3736, (Mouse) 16485, (Rat) 24520

Molecular Function: voltage-gated ion channel