This antibody is predicted to react with human based on sequence homology.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog. This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ25134; human brain potassium channel-2; kv2; MK1.6; potassium channel, voltage gated shaker related subfamily A, member 6; potassium channel-Kv2; potassium voltage gated channel, shaker related subfamily, member 6; potassium voltage gated channel, shaker related, subfamily, member 6; Potassium voltage-gated channel subfamily A member 6; potassium voltage-gated channel, shaker-related subfamily, member 6; protein phosphatase 1, regulatory subunit 96; RCK2; Voltage-gated potassium channel HBK2; voltage-gated potassium channel protein Kv1.6; Voltage-gated potassium channel subunit Kv1.6; voltage-gated potassium channel subunit Kv2
Gene Aliases: HBK2; KCNA6; KV1.6; MK1.6; PPP1R96
Molecular Function: voltage-gated ion channel