Suggested positive control: HEK293 cell lysate.
Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
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Protein Aliases: KV3.1; KV4; NGK2; Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991); potassium channel, voltage gated Shaw related subfamily C, member 1; potassium voltage gated channel, Shaw-related subfamily, member 1; Potassium voltage-gated channel subfamily C member 1; potassium voltage-gated channel, Shaw-related subfamily, member 1; RAW2; Shaw-related voltage-gated potassium channel protein 1; voltage-gated potassium channel KCNC1; voltage-gated potassium channel protein KV3.1; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
Gene Aliases: BOS_14495; C230009H10Rik; EPM7; KCNC1; Kcr2-1; KShIIIB; KV3.1; KV4; NGK2; NGK2-KV4; Shaw