In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Kallikrein 3, rhKallikrein 5, rhKallikrein 11, rhKallikrein 13, rhKallikrein 14, and rhKallikrein 15 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Kallikreins, including Kallikrein 6, are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease.
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Protein Aliases: kallikrein 6; kallikrein 7; Kallikrein-6; Kallikrein6; MGC9355; Neurosin; Protease M; Serine protease 18; Serine protease 9; SP59; Zyme
Gene Aliases: Bssp; hK6; KLK6; Klk7; PRSS18; PRSS9; SP59
UniProt ID: (Human) Q92876
Entrez Gene ID: (Human) 5653