This antibody detects Keratin 5 and 14 by Western blot at 58 kDa, corresponding to Keratin 5, and 50 kDa, corresponding to Keratin 14. Does not work on paraffin embedded tissue sections.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 58 kDa cytokeratin; CK-14; CK-5; cytokeratin 14; Cytokeratin-14; Cytokeratin-5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K14; K5; keratin 14, type I; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; Keratin, type I cytoskeletal 14; Keratin, type II cytoskeletal 5; Keratin-14; Keratin-5; Type-II keratin Kb5
Gene Aliases: CK14; CK5; DDD; DDD1; EBS2; EBS3; EBS4; K14; K5; KRT14; KRT5; KRT5A; NFJ