Product References
MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways.
Frontiers in oncology
Zhang X,Wang J,Wang Y,Liu G,Li H,Yu J,Wu R,Liang J,Yu R,Liu X
PA5-16446 was used in Immunohistochemistry to investigate the therapeutic effect of targeted inhibition of maternal embryonic leucine zipper kinase gene - MELK - on glioblastoma multiforme.
Sat Jul 16 00:00:00 EDT 2022
Quercetin-Rich Extracts from Onions (Allium cepa) Play Potent Cytotoxicity on Adrenocortical Carcinoma Cell Lines, and Quercetin Induces Important Anticancer Properties.
Pharmaceuticals (Basel, Switzerland)
Veiga AA,Irioda AC,Mogharbel BF,Bonatto SJR,Souza LM
PA5-16446 was used in Immunocytochemistry to support that quercetin-rich onions have the potential to be a natural source of anticancer agents for adrenocortical carcinoma.
Thu Jun 16 00:00:00 EDT 2022
Curative effect of methotrexate combined with teniposide in the treatment of primary central nervous system lymphoma.
Oncology letters
Wang YX,Huang Y,Xu XP,Chen BB,Lin ZG,Ma Y,Ding TL,Wang Q
PA5-16446 was used in Immunohistochemistry to investigate the curative effect of high-dose methotrexate (HD-MTX) combined with teniposide (Vm26) vs. HD-MTX alone in the treatment of primary central nervous system lymphoma (PCNSL), in order to provide data for assisting decisions associated with clinical treatment.
Sun Mar 01 00:00:00 EST 2020
Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome.
EMBO molecular medicine
Bertacchi M,Gruart A,Kaimakis P,Allet C,Serra L,Giacobini P,Delgado-García JM,Bovolenta P,Studer M
PA5-16446 was used in Immunohistochemistry-immunofluorescence to study the cellular mechanisms of optic nerve atrophy in Bosch-Boonstra-Schaaf optic atrophy syndrome.
Thu Aug 01 00:00:00 EDT 2019
Boiling Histotripsy Ablation of Renal Cell Carcinoma in the Eker Rat Promotes a Systemic Inflammatory Response.
Ultrasound in medicine & biology
Schade GR,Wang YN,D'Andrea S,Hwang JH,Liles WC,Khokhlova TD
Published figure using Ki-67 polyclonal antibody (Product # PA5-16446) in Immunohistochemistry
Tue Jan 01 00:00:00 EST 2019
Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall.
Brain structure & function
Žunić Išasegi I,Radoš M,Krsnik Ž,Radoš M,Benjak V,Kostović I
Published figure using Ki-67 polyclonal antibody (Product # PA5-16446) in Immunohistochemistry
Sat Dec 01 00:00:00 EST 2018
Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer.
PloS one
Fozzatti L,Park JW,Zhao L,Willingham MC,Cheng SY
PA5-16446 was used in immunohistochemistry to use a murine model of thyroid cancer to study the oncogenic activity of NCOR1
Tue Oct 10 00:00:00 EDT 2017
Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress.
Cell death & disease
Xia D,Ji W,Xu C,Lin X,Wang X,Xia Y,Lv P,Song Q,Ma D,Chen Y
Published figure using Ki-67 polyclonal antibody (Product # PA5-16446) in Immunohistochemistry
Thu Jul 27 00:00:00 EDT 2017
Ki-67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells.
Oncology letters
Bai Y,Shao Y,Li H,Xue W,Quan F,Wu S
Published figure using Ki-67 polyclonal antibody (Product # PA5-16446) in Western Blot
Sat Oct 01 00:00:00 EDT 2016
Ki-67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells.
Oncology letters
Bai Y,Shao Y,Li H,Xue W,Quan F,Wu S
Published figure using Ki-67 polyclonal antibody (Product # PA5-16446) in Western Blot
Sat Oct 01 00:00:00 EDT 2016
FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.
The Journal of clinical investigation
Haemmerle M,Bottsford-Miller J,Pradeep S,Taylor ML,Choi HJ,Hansen JM,Dalton HJ,Stone RL,Cho MS,Nick AM,Nagaraja AS,Gutschner T,Gharpure KM,Mangala LS,Rupaimoole R,Han HD,Zand B,Armaiz-Pena GN,Wu SY,Pecot CV,Burns AR,Lopez-Berestein G,Afshar-Kharghan V,Sood AK
PA5-16446 was used in immunohistochemistry - frozen section discuss targeting FAK and VEGF for ovarian cancer management
Mon May 02 00:00:00 EDT 2016
Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/β-Catenin Pathway by Its GAP Domain.
Frontiers in cellular neuroscience
Huang GH,Yang XT,Chen K,Xing J,Guo L,Zhu L,Li HJ,Li XC,Zhang SY,Feng DF
PA5-16446 was used in immunohistochemistry to investigate inhibition of neural stem cell proliferation through Wnt/beta-catenin pathway by its GAP domain via Porf-2
Tue Apr 12 00:00:00 EDT 2016
Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model.
Endocrine-related cancer
Park JW,Han CR,Zhao L,Willingham MC,Cheng SY
PA5-16446 was used in immunohistochemistry - paraffin section to study the delay of obesity-induced thyroid carcinogenesis in a mouse model by inhibition of STAT3 activity
Fri Jan 01 00:00:00 EST 2016
Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.
Scientific reports
Fu Y,Cruz-Monserrate Z,Helen Lin H,Chung Y,Ji B,Lin SM,Vonderfecht S,Logsdon CD,Li CF,Ann DK
PA5-16446 was used in immunohistochemistry - paraffin section to study induction of sarcomatoid phenotype solely due to ductal activation of oncogenic KRAS
Thu Aug 20 00:00:00 EDT 2015
Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo.
BMC cancer
Rowson-Hodel AR,Manjarin R,Trott JF,Cardiff RD,Borowsky AD,Hovey RC
PA5-16446 was used in immunohistochemistry to characterize porcine mammary epithelial cells in vitro and tumor formation in vivo and neoplastic transformation
Fri Jul 31 00:00:00 EDT 2015
Zbed3 contributes to malignant phenotype of lung cancer via regulating β-catenin and P120-catenin 1.
Molecular carcinogenesis
Fan C,Jiang G,Zhang X,Miao Y,Lin X,Luan L,Xu Z,Zhang Y,Zhao H,Liu D,Wang E
PA5-16446 was used in immunohistochemistry - paraffin section to investigate the role of Zbed3 in malignant phenotype of lung cancer
Mon Jun 01 00:00:00 EDT 2015
Oncogenic mutations of thyroid hormone receptor β.
Oncotarget
Park JW,Zhao L,Willingham M,Cheng SY
PA5-16446 was used in immunohistochemistry - paraffin section to analyze thyroid hormone receptor beta for oncogenic mutations
Fri Apr 10 00:00:00 EDT 2015
Curcumin: a unique antioxidant offers a multimechanistic approach for management of hepatocellular carcinoma in rat model.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Ahmed HH,Shousha WG,Shalby AB,El-Mezayen HA,Ismaiel NN,Mahmoud NS
PA5-16446 was used in immunohistochemistry - paraffin section to investigate the role of curcumin as a protective agent against hepatocellular carcinoma in rats
Sun Mar 01 00:00:00 EST 2015
The use of mouse models of breast cancer and quantitative image analysis to evaluate hormone receptor antigenicity after microwave-assisted formalin fixation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Engelberg JA,Giberson RT,Young LJ,Hubbard NE,Cardiff RD
PA5-16446 was used in immunohistochemistry to study hormone receptor immunogenicity following the use of rapid microwave-assisted formalin fixation of samples from murine models of breast cancer
Thu May 01 00:00:00 EDT 2014
Silencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo.
PloS one
Zhang L,Cui J,Leonard M,Nephew K,Li Y,Zhang X
PA5-16446 was used in immunohistochemistry to study the increased sensitivity of breast cancer cells to the estrogen receptor antagonist fulvestrant following knockdown of MED1
Tue Apr 01 00:00:00 EDT 2014
Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis.
PloS one
Barrett CW,Singh K,Motley AK,Lintel MK,Matafonova E,Bradley AM,Ning W,Poindexter SV,Parang B,Reddy VK,Chaturvedi R,Fingleton BM,Washington MK,Wilson KT,Davies SS,Hill KE,Burk RF,Williams CS
PA5-16446 was used in immunohistochemistry to study the mechanisms underlying the deleterious effects of selenium deficiency on experimental colitis and tumorigenesis in rat models
Mon Feb 03 00:00:00 EST 2014
CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells.
Molecular cancer research : MCR
Choi YH,Burdick MD,Strieter BA,Mehrad B,Strieter RM
PA5-16446 was used in immunohistochemistry to study non-small cell lung cancer metastasis and the relative contributions of CXCR4 and CXCR7
Wed Jan 01 00:00:00 EST 2014
Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.
PloS one
Hodgson MC,Vanostran G,Alghamdi S,Poppiti RJ,Agoulnik AI,Agoulnik IU
PA5-16446 was used in immunohistochemistry to study a murine model of ERBB2-induced breast tumor and the role of reduced androgen receptor levels in promoting malignant transformation
Tue Nov 05 00:00:00 EST 2013
Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression.
Disease models & mechanisms
Vinall RL,Chen JQ,Hubbard NE,Sulaimon SS,Shen MM,Devere White RW,Borowsky AD
PA5-16446 was used in immunohistochemistry to study the role of the R270H mutant form of Tp53 in the initiation of prostate cancer in a murine model
Thu Nov 01 00:00:00 EDT 2012
Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma.
PloS one
Holmberg J,He X,Peredo I,Orrego A,Hesselager G,Ericsson C,Hovatta O,Oba-Shinjo SM,Marie SK,Nistér M,Muhr J
PA5-16446 was used in immunohistochemistry - paraffin section to examine human gliomas of various malignancy grades for the expression of stem cell regulatory proteins
Thu Mar 31 00:00:00 EDT 2011
