Invitrogen

Ki-67 Monoclonal Antibody (SolA15), Biotin, eBioscience™

Product Image Gallery

Ki-67 Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry of fixed and permeabilized C2C12 cells stained with 5 µg/mL of Rat IgG2a K Isotype Control Biotin (left) or 5 µg/mL of Anti-Mouse/Rat Ki-67 Biotin (right) followed by Streptavidin FITC. Nuclei are stained with DAPI, colocalization of signal with DAPI appears aqua.

Ki-67 Antibody in Western Blot, Immunohistochemistry, Flow Cytometry (WB, IHC, Flow) — Figure 3. Mouse development with a mutated Ki-67 gene. ( A ) Table describing Ki-67 mutant mouse lines resulting from germline transmission of mutations generated by cytoplasmic injection of TALEN-encoding mRNA into zygotes. ( B ) Macroscopic appearance of littermate female mice at 10 weeks of age. Genotypes are specified. ( C ) IHC staining of Ki-67 in sagittal section of intestine from Mki67 WT/WT , Mki67 WT/2nt and Mki67 2nt/2nt mice. ( D ) Western blots of Ki-67 and cyclin A expression from intestine isolated from Mki67 WT/WT , Mki67 WT/2nt and Mki67 2nt/2nt mice. LC, loading control. ( E ) Western blot of Ki-67 in MEFs from WT, Mki67 WT/2nt and Mki67 2nt/2nt mice. LC, loading control. ( F ) Flow cytometry profiles in WT, Mki67 WT/2nt and Mki67 2nt/2nt MEFs showing EdU incorporation upon a 1 hr pulse and DNA content. DOI: http://dx.doi.org/ Figure 3--figure supplement 1. Ki-67 mutant mice develop normally. ( A ) Pair of TALE-nucleases designed to target the initiator ATG of mouse Mki67 gene. ( B ) Sequencing traces of initiator ATG (underlined) of Mki67 gene in WT Mki67 +/+ (WT/WT), heterozygous Mki67 +/2nt (WT/2nt) and homozygous Mki67 2nt/2nt (2nt/2nt) mice. ( C ) Sequencing traces of initiator ATG (underlined) of Mki67 gene in WT Mki67 +/+ (WT/WT), heterozygous Mki67 +/21nt (WT/21nt) and homozygous Mki67 21nt/21nt (21nt/21nt) mice. ( D ) WT Mki67 +/+ (+/+), heterozygous Mki67 +/21nt (+/21nt) and homozygous Mki67 21nt/21nt (21nt/21nt) mice. DOI: http://dx.doi.org/ Figur

Ki-67 Antibody in Western Blot (WB) — Figure 5. Cells lacking Ki-67 enter the cell cycle efficiently. ( A ) Top, re-entry of cell cycle in NIH-3T3 WT clone W4 and Ki-67-negative mutant clones 60 and 65 after serum starvation-induced cell cycle arrest. Progression of cell cycle entry analysed by FACS using EdU staining. Bottom, quantification of cell cycle phases in this experiment. ( B ) Western blot analysis of Ki-67 (upper panel) and cyclin A2 (lower panel) upon cell cycle entry. LC, loading control. DOI: http://dx.doi.org/ Figure 5--figure supplement 1. Cells lacking Ki-67 proliferate efficiently. ( A ) Schematic presentation of generation of Ki-67 shRNA knockdown BJ-hTERT. ( B ) Left, Western blot for indicated proteins upon cell cycle re-entry in serum starved hTERT-transformed BJ fibroblasts (BJ-hTERT) after induction of shRNA against Ki-67 (+) or GAPDH control (-). LC, loading control. Right, DNA synthesis analysed by flow cytometry after EdU pulse. ( C ) Left, asynchronous BJ-hTERT with doxycyclin-induced control or Ki-67 shRNA-expression were additionally transfected with control or Ki-67 siRNA for 48 hr. Protein levels were analysed by Western blotting. LC, loading control. Right, cell cycle distribution by flow cytometry. DOI: http://dx.doi.org/ Figure 5--figure supplement 2. Cells lacking Ki-67 proliferate efficiently. ( A ) Schematic presentation of generation of Ki-67 shRNA knockdown cell lines. ( B ) Top: Western blot analysis of the indicated proteins in asynchronously growing U2OS and HeLa cells

Ki-67 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF) — Figure 4. Cell proliferation without Ki-67. ( A ) Schematic representation of strategy for TALEN-mediated generation of Mki67 null allele. ( B ) qRT-PCR analysis of Ki-67 mRNA levels in NIH-3T3 WT clone W4 and Ki-67-negative 60, 65, 99 clones. ( C ) Top: Western blot of Ki-67 and Cyclin A in NIH-3T3 WT clone W4 and Ki-67-negative mutant clones 60, 65, 99; LC, loading control; below, Ki-67 immunofluorescence; bar, 10 um. ( D ) Left, growth curves of WT and Ki-67 null cell lines 60, 65 and 99; right, cell cycle distribution analysed by flow cytometry. ( E ) Cell cycle length of WT clone W4 and Ki-67 null clones 60 and 65 as determined by time-lapse videomicroscopy. ( F ) Cells of clone 65 show altered chromosomal periphery in mitosis. The Ki-67 staining is deliberately overexposed to demonstrate absence of detectable Ki-67 in clone 65, even in metaphase. Bar, 5 um. DOI: http://dx.doi.org/ Figure 4--figure supplement 1. Generation of NIH-3T3 cells lacking Ki-67. Top, schematic representation of the wild type (WT), knock-out or eGFP knock-in Mki67 locus and the predicted insertion of tandem repeats of the eGFP insert upstream of Mki67 locus. Bottom, Southern-blot of two NIH-3T3 WT clones (WT, W4) and six NIH-3T3 Ki-67 mutant clones (60,63,65,82,99). Clones were digested with PstI or SphI and probed with 5' or 3' probe, respectively. DOI: http://dx.doi.org/

Ki-67 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow) — Figure 5. mTORC1 inhibition fails to drive activated SSC accumulation and early progenitor depletion in the absence of intercellular bridges (A and B) WM-IIF of PLZF (green, spermatogonia), RARgamma (red, late progenitors), SOX3 (white, early/late progenitors) or KIT (white, differentiating spermatogonia), and Ki67 (blue, proliferation) in seminiferous tubules from P36 Tex14 -/- mice. Arrowhead, quiescent SSCs (PLZF+/SOX3-/RARgamma/Ki67-) or early progenitors (PLZF+/KIT-/RARgamma-/Ki67-); arrow, activated SSCs (PLZF+/SOX3-/RARgamma-/Ki67+) or early progenitors (PLZF+/KIT-/RARgamma-/Ki67+); circle, early progenitors (PLZF+/SOX3+/RARgamma-/Ki67+); asterisk, late progenitors (PLZF+/SOX3+ or KIT-/RARgamma+/Ki67-). Scale bar, 20 mum. (C) Proportion of SSCs (KIT-/PLZF low /SOX3 low /RARgamma low ), early progenitors (KIT-/PLZF low /SOX3 high /RARgamma low ), and late progenitors (KIT-/PLZF high /SOX3 high /RARgamma high ) in seminiferous tubule cells from control (n = 3) and rapamycin-treated (n = 3) Tex14 -/- mice at P36 (see controls in Figure S3J ). Data are mean +- SEM. (D) Ki67 staining intensity in SSCs (KIT-/PLZF low /SOX3 low /RARgamma low ), early progenitors (KIT-/PLZF low /SOX3 high /RARgamma low ), and late progenitors (KIT-/PLZF high /SOX3 high /RARgamma high ) in seminiferous tubule cells from Tex14 +/- , Tex14 -/- , and rapamycin-treated Tex14 -/- mice (n = 3 each) at P36 (see controls in Figure S3J ). Data are mean +- SEM. Two-tailed Student''s t test (***p < 0.001)

Ki-67 Antibody in Immunocytochemistry, Immunohistochemistry (Paraffin) (ICC/IF, IHC (P)) — Figure 1 (A) Scheme of experiments. (B) Representative image (at 10X, transmitted light microscopy) of GBM143 xenograft line cultured for 3 weeks in vitro in media indicated; cells were collected and orthotopically implanted into cranially irradiated mice 24 hrs post-irradiation (IR). (C) Representative Immunofluorescence (IF) images (at 4X, tiling) for hLamin A+C staining from 0 Gy and 20 Gy-IR mice coronal sections to assess tumor growth and invasion. (D) Top: Representative images (at 20X) show IF staining at tumor; and the dot-plot of single cell count for hLamin A+C and Ki67 staining. Bottom: Representative images (at 20X) show IF staining at center of corpus callosum, and dot-plot of single cell count for hLamin A+C. IH, ipsilateral hemisphere; CH, contralateral hemisphere; IR, irradiation. Statistical significance is represented as * p < 0.05.

Ki-67 Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC) — Figure 2. Shh signaling is highly activated in HOPX-positive oRG cells and prevents HOPX-positive oRG cells from differentiating. ( A ) Sagittal sections of the ferret brain at P6 were subjected to in situ hybridization for GLI1 and Hoechst 33342 staining. Asterisks indicate areas of prospective sulci. A higher-magnification image of the germinal zone is shown in the lower panel. Five regions (boxes, #1-#5) based on the positions of prospective gyri and sulci in the left panels were magnified and are shown in the right panels. GLI1 was more abundantly expressed in the OSVZ of prospective gyri (#1, 3, 5) than in that of prospective sulci (#2, 4). A, anterior; P, posterior.Scale bars = 2 mm (left, upper), 1 mm (left, lower), 200 mum (right). ( B ) Sections of the ferret cerebral cortex at P1 were subjected to in situ hybridization for GLI1 and immunohistochemistry for Pax6 and Tbr2. High-magnification images of the OSVZ are shown. GLI1 was mainly expressed in oRG cells (Pax6-positive and Tbr2-negative, arrowheads). Scale bar = 20 mum. ( C ) Sections of the ferret cerebral cortex at P1 were subjected to in situ hybridization for GLI1 and immunohistochemistry for Pax6, Tbr2 and HOPX. High-magnification images of the OSVZ are shown. GLI1 -positive oRG cells were mainly HOPX-positive (arrowheads), rather than HOPX-negative (open arrowhead). Scale bar = 20 mum. ( D ) Percentage of GLI1 -positive cells co-expressing Pax6 and/or Tbr2. n = 3 animals. ( E ) Percentage of GLI1 -positive

Product Details

13-5698-82

Applications	Tested Dilution	Publications
Western Blot (WB)	-	View 1 publication 1 publication
Immunohistochemistry (IHC)	-	View 57 publications 57 publications
Immunohistochemistry (Paraffin) (IHC (P))	Assay-Dependent	View 2 publications 2 publications
Immunohistochemistry (Frozen) (IHC (F))	Assay-Dependent	-
Immunocytochemistry (ICC/IF)	5 µg/mL	View 34 publications 34 publications
Flow Cytometry (Flow)	0.125 µg/test	View 43 publications 43 publications
Functional Assay (FN)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Dog, Cynomolgus monkey, Human, Mouse, Non-human primate, Rat
Published species	Human, Mouse, Rat
Host/Isotype	Rat / IgG2a, kappa
Recommended Isotype Control	Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience™
Class	Monoclonal
Type	Antibody
Clone	SolA15
Conjugate	Biotin Alexa Fluor 488 Alexa Fluor 532 Alexa Fluor 660 Alexa Fluor 700 APC APC-eFluor 780 Brilliant UV 737 Brilliant UV 805 eFluor 450 eFluor 506 eFluor 570 eFluor 615 eFluor 660 FITC PE PE-Cyanine5 PE-Cyanine7 PE-eFluor 610 PerCP-eFluor 710 Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.2
Contains	0.09% sodium azide
Storage conditions	4° C, store in dark, DO NOT FREEZE!
RRID	AB_2572794

Product Specific Information

Description: The monoclonal antibody SolA15 recognizes mouse and rat Ki-67, a 300 kDa nuclear protein. Ki-67 is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0). Ki-67 is detected within the nucleus during interphase but redistributes to the chromosomes during mitosis. Ki-67 is used as a marker for determining the growth fraction of a given population of cells. In studies of tumor cells, the "Ki-67 labeling index" refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types. Ki-67 has been shown to interact with the DNA-bound protein chromobox protein homolog 3 (CBX3) (heterochromatin).

The SolA15 antibody also recognizes human, non-human primate and canine Ki-67.

Applications Reported: This SolA15 antibody has been reported for use in intracellular staining followed by flow cytometric analysis, immunohistochemical staining of frozen tissue sections, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry.

Applications Tested: This SolA15 antibody has been tested immunocytochemistry of fixed and permeabilized C2C12 cells and can be used at less than or equal to 5 µg/mL or intracellular staining and flow cytometric analysis of stimulated mous esplenocytes cells using the Foxp3/Transcription Factor Buffer Set (cat. 00-5523) and protocol. Please see Best Protocols Section (Staining intracellular Antigens for Flow Cytometry) for staining protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins). This can be used at less than or equal to 0.125 µg per test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.

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Ten-eleven translocation protein 1 modulates medulloblastoma progression.

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Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

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Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung.

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CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.

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Field size effects on DNA damage and proliferation in normal human cell populations irradiated with X-ray microbeams.

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Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

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Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

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Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

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Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Wed Oct 28 00:00:00 EDT 2020

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Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Thu Oct 22 00:00:00 EDT 2020

Mycobacterium tuberculosis-infected alveolar epithelial cells modulate dendritic cell function through the HIF-1α-NOS2 axis.

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Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST.

Frontiers in cellular neuroscience

Stratton JA,Assinck P,Sinha S,Kumar R,Moulson A,Patrick N,Raharjo E,Chan JA,Midha R,Tetzlaff W,Biernaskie J

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Thu Oct 01 00:00:00 EDT 2020

Novel enhanced GFP-positive congenic inbred strain establishment and application of tumor-bearing nude mouse model.

Cancer science

Lan Q,Chen Y,Dai C,Li S,Fei X,Dong J,Shen Y,Dai X,Lu Z,Liu B,Wang Q,Wang H,Zhou Z,Ji X,Wang Z,Huang Q

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Thu Oct 01 00:00:00 EDT 2020

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma.

Frontiers in oncology

Gupta K,Vuckovic I,Zhang S,Xiong Y,Carlson BL,Jacobs J,Olson I,Petterson XM,Macura SI,Sarkaria J,Burns TC

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Mon Sep 28 00:00:00 EDT 2020

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma.

Frontiers in oncology

Gupta K,Vuckovic I,Zhang S,Xiong Y,Carlson BL,Jacobs J,Olson I,Petterson XM,Macura SI,Sarkaria J,Burns TC

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Mon Sep 28 00:00:00 EDT 2020

The effects of hedgehog ligand neutralising antibody 5E1 in a mouse model of endometriosis.

BMC research notes

Cousins FL,Farley JK,Kerrigan R,Mukherjee S,Darzi S,Gargett CE,Deane JA

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Fri Sep 25 00:00:00 EDT 2020

Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.

Nucleic acids research

Wüst HM,Wegener A,Fröb F,Hartwig AC,Wegwitz F,Kari V,Schimmel M,Tamm ER,Johnsen SA,Wegner M,Sock E

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Fri Sep 18 00:00:00 EDT 2020

Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion.

Cell reports

Drareni K,Ballaire R,Alzaid F,Goncalves A,Chollet C,Barilla S,Nguewa JL,Dias K,Lemoine S,Riveline JP,Roussel R,Dalmas E,Velho G,Treuter E,Gautier JF,Venteclef N

13-5698 was used in Immunohistochemistry-immunofluorescence to examine whether GPS2 controls the reprogramming of white adipocytes to influence pancreatic islet function and insulin secretion.

Tue Sep 15 00:00:00 EDT 2020

FGF2 modulates simultaneously the mode, the rate of division and the growth fraction in cultures of radial glia.

Development (Cambridge, England)

Ledesma-Terrón M,Peralta-Cañadas N,Míguez DG

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Fri Jul 24 00:00:00 EDT 2020

Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction.

PloS one

Gladow N,Hollmann C,Ramos G,Frantz S,Kerkau T,Beyersdorf N,Hofmann U

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons.

eLife

Okaty BW,Sturrock N,Escobedo Lozoya Y,Chang Y,Senft RA,Lyon KA,Alekseyenko OV,Dymecki SM

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Mon Jun 22 00:00:00 EDT 2020

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Thu Jun 11 00:00:00 EDT 2020

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.

The Journal of experimental medicine

Hermanova I,Zúñiga-García P,Caro-Maldonado A,Fernandez-Ruiz S,Salvador F,Martín-Martín N,Zabala-Letona A,Nuñez-Olle M,Torrano V,Camacho L,Lizcano JM,Talamillo A,Carreira S,Gurel B,Cortazar AR,Guiu M,López JI,Martinez-Romero A,Astobiza I,Valcarcel-Jimenez L,Lorente M,Arruabarrena-Aristorena A,Velasco G,Gomez-Muñoz A,Suárez-Cabrera C,Lodewijk I,Flores JM,Sutherland JD,Barrio R,de Bono JS,Paramio JM,Trka J,Graupera M,Gomis RR,Carracedo A

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Transcriptome analysis of basic fibroblast growth factor treated stem cells isolated from human exfoliated deciduous teeth.

Heliyon

Nowwarote N,Manokawinchoke J,Kanjana K,Fournier BPJ,Sukarawan W,Osathanon T

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Mon Jun 01 00:00:00 EDT 2020

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.

Nature communications

Riedel R,Addo R,Ferreira-Gomes M,Heinz GA,Heinrich F,Kummer J,Greiff V,Schulz D,Klaeden C,Cornelis R,Menzel U,Kröger S,Stervbo U,Köhler R,Haftmann C,Kühnel S,Lehmann K,Maschmeyer P,McGrath M,Naundorf S,Hahne S,Sercan-Alp Ö,Siracusa F,Stefanowski J,Weber M,Westendorf K,Zimmermann J,Hauser AE,Reddy ST,Durek P,Chang HD,Mashreghi MF,Radbruch A

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.

Nature communications

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.

eLife

Matsumoto N,Tanaka S,Horiike T,Shinmyo Y,Kawasaki H

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Tue Apr 21 00:00:00 EDT 2020

A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.

eLife

Matsumoto N,Tanaka S,Horiike T,Shinmyo Y,Kawasaki H

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Tue Apr 21 00:00:00 EDT 2020

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.

Nature communications

Pein M,Insua-Rodríguez J,Hongu T,Riedel A,Meier J,Wiedmann L,Decker K,Essers MAG,Sinn HP,Spaich S,Sütterlin M,Schneeweiss A,Trumpp A,Oskarsson T

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Fri Mar 20 00:00:00 EDT 2020

Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung.

Developmental cell

Vila Ellis L,Cain MP,Hutchison V,Flodby P,Crandall ED,Borok Z,Zhou B,Ostrin EJ,Wythe JD,Chen J

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Mon Mar 09 00:00:00 EDT 2020

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Cell reports

Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Jan 21 00:00:00 EST 2020

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Cell reports

Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Jan 21 00:00:00 EST 2020

Interleukin-13 disrupts type 2 pneumocyte stem cell activity.

JCI insight

Glisinski KM,Schlobohm AJ,Paramore SV,Birukova A,Moseley MA,Foster MW,Barkauskas CE

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Thu Jan 16 00:00:00 EST 2020

Interleukin-13 disrupts type 2 pneumocyte stem cell activity.

JCI insight

Glisinski KM,Schlobohm AJ,Paramore SV,Birukova A,Moseley MA,Foster MW,Barkauskas CE

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Thu Jan 16 00:00:00 EST 2020

Chemosensitization of prostate cancer stem cells in mice by angiogenin and plexin-B2 inhibitors.

Communications biology

Li S,Goncalves KA,Lyu B,Yuan L,Hu GF

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Wed Jan 15 00:00:00 EST 2020

Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.

Clinical and experimental pharmacology & physiology

Bose P,Siddique MUM,Acharya R,Jayaprakash V,Sinha BN,Lapenna A,Pattanayak SP

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Wed Jan 01 00:00:00 EST 2020

JAK-STAT inhibition impairs K-RAS-driven lung adenocarcinoma progression.

International journal of cancer

Mohrherr J,Haber M,Breitenecker K,Aigner P,Moritsch S,Voronin V,Eferl R,Moriggl R,Stoiber D,Győrffy B,Brcic L,László V,Döme B,Moldvay J,Dezső K,Bilban M,Popper H,Moll HP,Casanova E

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Sun Dec 15 00:00:00 EST 2019

1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8⁺ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.

Frontiers in immunology

Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.

Frontiers in immunology

Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Sep 26 00:00:00 EDT 2019

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

The Journal of experimental medicine

Fujino N,Brand OJ,Morgan DJ,Fujimori T,Grabiec AM,Jagger CP,Maciewicz RA,Yamada M,Itakura K,Sugiura H,Ichinose M,Hussell T

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Sep 02 00:00:00 EDT 2019

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

The Journal of experimental medicine

Fujino N,Brand OJ,Morgan DJ,Fujimori T,Grabiec AM,Jagger CP,Maciewicz RA,Yamada M,Itakura K,Sugiura H,Ichinose M,Hussell T

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Sep 02 00:00:00 EDT 2019

SORLA regulates endosomal trafficking and oncogenic fitness of HER2.

Nature communications

Pietilä M,Sahgal P,Peuhu E,Jäntti NZ,Paatero I,Närvä E,Al-Akhrass H,Lilja J,Georgiadou M,Andersen OM,Padzik A,Sihto H,Joensuu H,Blomqvist M,Saarinen I,Boström PJ,Taimen P,Ivaska J

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Tue May 28 00:00:00 EDT 2019

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

The Journal of biological chemistry

Singh A,Mia MM,Cibi DM,Arya AK,Bhadada SK,Singh MK

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Fri May 24 00:00:00 EDT 2019

FCRL5⁺ Memory B Cells Exhibit Robust Recall Responses.

Cell reports

Kim CC,Baccarella AM,Bayat A,Pepper M,Fontana MF

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Tue Apr 30 00:00:00 EDT 2019

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.

Cell reports

Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Tue Apr 16 00:00:00 EDT 2019

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Immunity

Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Apr 16 00:00:00 EDT 2019

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Immunity

Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Apr 16 00:00:00 EDT 2019

Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.

Nature communications

Cheng HW,Onder L,Novkovic M,Soneson C,Lütge M,Pikor N,Scandella E,Robinson MD,Miyazaki JI,Tersteegen A,Sorg U,Pfeffer K,Rülicke T,Hehlgans T,Ludewig B

13-5698 was used in Immunohistochemistry to establish fibroblastic reticular cell (FRC)- specific fate-mapping in mice to identify the embryonic origin and differentiation trajectories in the splenic white pulp.

Mon Apr 15 00:00:00 EDT 2019

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.

Cell stem cell

Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK

13-5698 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.

Thu Apr 04 00:00:00 EDT 2019

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

Nature communications

Zhong L,Xu Y,Zhuo R,Wang T,Wang K,Huang R,Wang D,Gao Y,Zhu Y,Sheng X,Chen K,Wang N,Zhu L,Can D,Marten Y,Shinohara M,Liu CC,Du D,Sun H,Wen L,Xu H,Bu G,Chen XF

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Mon Mar 25 00:00:00 EDT 2019

Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.

Nature communications

Akram KM,Yates LL,Mongey R,Rothery S,Gaboriau DCA,Sanderson J,Hind M,Griffiths M,Dean CH

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Mar 12 00:00:00 EDT 2019

Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.

Nature communications

Akram KM,Yates LL,Mongey R,Rothery S,Gaboriau DCA,Sanderson J,Hind M,Griffiths M,Dean CH

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Mar 12 00:00:00 EDT 2019

C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats.

BioMed research international

Dergilev K,Tsokolaeva Z,Makarevich P,Beloglazova I,Zubkova E,Boldyreva M,Ratner E,Dyikanov D,Menshikov M,Ovchinnikov A,Ageev F,Parfyonova Y

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Jan 14 00:00:00 EST 2019

Comprehensive and cell-type-based characterization of the dorsal midbrain during development.

Genes to cells : devoted to molecular & cellular mechanisms

Arimura N,Dewa KI,Okada M,Yanagawa Y,Taya SI,Hoshino M

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Tue Jan 01 00:00:00 EST 2019

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.

Nature communications

Koren E,Yosefzon Y,Ankawa R,Soteriou D,Jacob A,Nevelsky A,Ben-Yosef R,Bar-Sela G,Fuchs Y

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Fri Nov 02 00:00:00 EDT 2018

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Developmental cell

Sznurkowska MK,Hannezo E,Azzarelli R,Rulands S,Nestorowa S,Hindley CJ,Nichols J,Göttgens B,Huch M,Philpott A,Simons BD

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Aug 06 00:00:00 EDT 2018

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Developmental cell

Sznurkowska MK,Hannezo E,Azzarelli R,Rulands S,Nestorowa S,Hindley CJ,Nichols J,Göttgens B,Huch M,Philpott A,Simons BD

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Aug 06 00:00:00 EDT 2018

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.

Cell

Schneider C,O'Leary CE,von Moltke J,Liang HE,Ang QY,Turnbaugh PJ,Radhakrishnan S,Pellizzon M,Ma A,Locksley RM

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Jul 12 00:00:00 EDT 2018

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment.

Investigative ophthalmology & visual science

Kiang L,Ross BX,Yao J,Shanmugam S,Andrews CA,Hansen S,Besirli CG,Zacks DN,Abcouwer SF

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Jul 02 00:00:00 EDT 2018

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.

Nature communications

Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Fri Jun 22 00:00:00 EDT 2018

The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis.

Oncotarget

Jurisevic M,Arsenijevic A,Pantic J,Gajovic N,Milovanovic J,Milovanovic M,Poljarevic J,Sabo T,Vojvodic D,Radosavljevic GD,Arsenijevic N

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.

Nature medicine

Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Journal of translational medicine

Moll S,Yasui Y,Abed A,Murata T,Shimada H,Maeda A,Fukushima N,Kanamori M,Uhles S,Badi L,Cagarelli T,Formentini I,Drawnel F,Georges G,Bergauer T,Gasser R,Bonfil RD,Fridman R,Richter H,Funk J,Moeller MJ,Chatziantoniou C,Prunotto M

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry (Paraffin)

Fri Jun 01 00:00:00 EDT 2018

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.

Cancer cell

Arce Vargas F,Furness AJS,Litchfield K,Joshi K,Rosenthal R,Ghorani E,Solomon I,Lesko MH,Ruef N,Roddie C,Henry JY,Spain L,Ben Aissa A,Georgiou A,Wong YNS,Smith M,Strauss D,Hayes A,Nicol D,O'Brien T,Mårtensson L,Ljungars A,Teige I,Frendéus B,Pule M,Marafioti T,Gore M,Larkin J,Turajlic S,Swanton C,Peggs KS,Quezada SA

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Apr 09 00:00:00 EDT 2018

Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.

Nature communications

Lopes N,Charaix J,Cédile O,Sergé A,Irla M

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion.

Cell reports

Böni-Schnetzler M,Häuselmann SP,Dalmas E,Meier DT,Thienel C,Traub S,Schulze F,Steiger L,Dror E,Martin P,Herrera PL,Gabay C,Donath MY

13-5698 was used in Immunohistochemistry to investigate the protective role of local Interleukin-1 receptor antagonist (IL-1Ra) in pancreatic islet Β cell-specific versus myeloid-cell-specific IL-1Ra knockout mice.

Tue Feb 13 00:00:00 EST 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Cell

Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Schultze JL,Wielockx B,Zamboni N,Mirtschink P,Coskun Ü,Hajishengallis G,Netea MG,Chavakis T

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Jan 11 00:00:00 EST 2018

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice.

International journal of molecular medicine

Nguyễn-Thanh T,Kim D,Lee S,Kim W,Park SK,Kang KP

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Jan 01 00:00:00 EST 2018

Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer.

Biomaterials

Miller-Kleinhenz J,Guo X,Qian W,Zhou H,Bozeman EN,Zhu L,Ji X,Wang YA,Styblo T,O'Regan R,Mao H,Yang L

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Jan 01 00:00:00 EST 2018

Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer.

Biomaterials

Miller-Kleinhenz J,Guo X,Qian W,Zhou H,Bozeman EN,Zhu L,Ji X,Wang YA,Styblo T,O'Regan R,Mao H,Yang L

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Jan 01 00:00:00 EST 2018

White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection.

Immunity

Han SJ,Glatman Zaretsky A,Andrade-Oliveira V,Collins N,Dzutsev A,Shaik J,Morais da Fonseca D,Harrison OJ,Tamoutounour S,Byrd AL,Smelkinson M,Bouladoux N,Bliska JB,Brenchley JM,Brodsky IE,Belkaid Y

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Tue Dec 19 00:00:00 EST 2017

Neonatal pancreatic pericytes support β-cell proliferation.

Molecular metabolism

Epshtein A,Rachi E,Sakhneny L,Mizrachi S,Baer D,Landsman L

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle.

The Journal of biological chemistry

Kamizaki K,Doi R,Hayashi M,Saji T,Kanagawa M,Toda T,Fukada SI,Ho HH,Greenberg ME,Endo M,Minami Y

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Fri Sep 22 00:00:00 EDT 2017

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.

Nature

Mass E,Jacome-Galarza CE,Blank T,Lazarov T,Durham BH,Ozkaya N,Pastore A,Schwabenland M,Chung YR,Rosenblum MK,Prinz M,Abdel-Wahab O,Geissmann F

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Sep 21 00:00:00 EDT 2017

Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.

The Journal of clinical investigation

Zang S,Li J,Yang H,Zeng H,Han W,Zhang J,Lee M,Moczygemba M,Isgandarova S,Yang Y,Zhou Y,Rao A,You MJ,Sun D,Huang Y

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.

Scientific reports

Shintani Y,Ito T,Fields L,Shiraishi M,Ichihara Y,Sato N,Podaru M,Kainuma S,Tanaka H,Suzuki K

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Mon Jul 31 00:00:00 EDT 2017

De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.

Cell

Ghoneim HE,Fan Y,Moustaki A,Abdelsamed HA,Dash P,Dogra P,Carter R,Awad W,Neale G,Thomas PG,Youngblood B

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Jun 29 00:00:00 EDT 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.

Nature communications

Contrepois K,Coudereau C,Benayoun BA,Schuler N,Roux PF,Bischof O,Courbeyrette R,Carvalho C,Thuret JY,Ma Z,Derbois C,Nevers MC,Volland H,Redon CE,Bonner WM,Deleuze JF,Wiel C,Bernard D,Snyder MP,Rübe CE,Olaso R,Fenaille F,Mann C

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Wed May 10 00:00:00 EDT 2017

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Nature

Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Apr 06 00:00:00 EDT 2017

Differential cytokine contributions of perivascular haematopoietic stem cell niches.

Nature cell biology

Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice.

Nature medicine

Liang J,Zhang Y,Xie T,Liu N,Chen H,Geng Y,Kurkciyan A,Mena JM,Stripp BR,Jiang D,Noble PW

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunocytochemistry

Tue Nov 01 00:00:00 EDT 2016

Whole Chromosome Instability induces senescence and promotes SASP.

Scientific reports

Andriani GA,Almeida VP,Faggioli F,Mauro M,Tsai WL,Santambrogio L,Maslov A,Gadina M,Campisi J,Vijg J,Montagna C

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Wed Oct 12 00:00:00 EDT 2016

Whole Chromosome Instability induces senescence and promotes SASP.

Scientific reports

Andriani GA,Almeida VP,Faggioli F,Mauro M,Tsai WL,Santambrogio L,Maslov A,Gadina M,Campisi J,Vijg J,Montagna C

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Wed Oct 12 00:00:00 EDT 2016

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Thu Oct 06 00:00:00 EDT 2016

Schwann cell proliferation and differentiation that is induced by ferulic acid through MEK1/ERK1/2 signalling promotes peripheral nerve remyelination following crush injury in rats.

Experimental and therapeutic medicine

Zhu X,Li K,Guo X,Wang J,Xiang Y

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.

eLife

Ramo K,Sugamura K,Craige S,Keaney JF,Davis RJ

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Aug 09 00:00:00 EDT 2016

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

JCI insight

Sato Y,Mii A,Hamazaki Y,Fujita H,Nakata H,Masuda K,Nishiyama S,Shibuya S,Haga H,Ogawa O,Shimizu A,Narumiya S,Kaisho T,Arita M,Yanagisawa M,Miyasaka M,Sharma K,Minato N,Kawamoto H,Yanagita M

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Thu Jul 21 00:00:00 EDT 2016

Detection of Cell Proliferation Markers by Immunofluorescence Staining and Microscopy Imaging in Paraffin-Embedded Tissue Sections.

Current protocols in molecular biology

Eminaga S,Teekakirikul P,Seidman CE,Seidman JG

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Fri Jul 01 00:00:00 EDT 2016

RANKL/RANK control Brca1 mutation- .

Cell research

Sigl V,Owusu-Boaitey K,Joshi PA,Kavirayani A,Wirnsberger G,Novatchkova M,Kozieradzki I,Schramek D,Edokobi N,Hersl J,Sampson A,Odai-Afotey A,Lazaro C,Gonzalez-Suarez E,Pujana MA,Cimba F,Heyn H,Vidal E,Cruickshank J,Berman H,Sarao R,Ticevic M,Uribesalgo I,Tortola L,Rao S,Tan Y,Pfeiler G,Lee EY,Bago-Horvath Z,Kenner L,Popper H,Singer C,Khokha R,Jones LP,Penninger JM

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Fri Jul 01 00:00:00 EDT 2016

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

Nature

Fox RG,Lytle NK,Jaquish DV,Park FD,Ito T,Bajaj J,Koechlein CS,Zimdahl B,Yano M,Kopp J,Kritzik M,Sicklick J,Sander M,Grandgenett PM,Hollingsworth MA,Shibata S,Pizzo D,Valasek M,Sasik R,Scadeng M,Okano H,Kim Y,MacLeod AR,Lowy AM,Reya T

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Thu Jun 16 00:00:00 EDT 2016

Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma.

Oncoimmunology

Büchel G,Schulte JH,Harrison L,Batzke K,Schüller U,Hansen W,Schramm A

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.

Science (New York, N.Y.)

Soucie EL,Weng Z,Geirsdóttir L,Molawi K,Maurizio J,Fenouil R,Mossadegh-Keller N,Gimenez G,VanHille L,Beniazza M,Favret J,Berruyer C,Perrin P,Hacohen N,Andrau JC,Ferrier P,Dubreuil P,Sidow A,Sieweke MH

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Fri Feb 12 00:00:00 EST 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.

Journal of cell science

Barazzuol L,Rickett N,Ju L,Jeggo PA

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2015

Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage.

Stem cell reports

Chang CH,Zhang M,Rajapakshe K,Coarfa C,Edwards D,Huang S,Rosen JM

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.

Nature medicine

Lovisa S,LeBleu VS,Tampe B,Sugimoto H,Vadnagara K,Carstens JL,Wu CC,Hagos Y,Burckhardt BC,Pentcheva-Hoang T,Nischal H,Allison JP,Zeisberg M,Kalluri R

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Tue Sep 01 00:00:00 EDT 2015

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.

Nature communications

Yan S,Xu Z,Lou F,Zhang L,Ke F,Bai J,Liu Z,Liu J,Wang H,Zhu H,Sun Y,Cai W,Gao Y,Su B,Li Q,Yang X,Yu J,Lai Y,Yu XZ,Zheng Y,Shen N,Chin YE,Wang H

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunohistochemistry

Fri Jul 03 00:00:00 EDT 2015

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.

Nature communications

Giera S,Deng Y,Luo R,Ackerman SD,Mogha A,Monk KR,Ying Y,Jeong SJ,Makinodan M,Bialas AR,Chang BS,Stevens B,Corfas G,Piao X

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Wed Jan 21 00:00:00 EST 2015

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.

PloS one

Liu J,Copland DA,Horie S,Wu WK,Chen M,Xu Y,Paul Morgan B,Mack M,Xu H,Nicholson LB,Dick AD

Thu Jan 15 00:00:00 EST 2015

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.

PloS one

Liu J,Copland DA,Horie S,Wu WK,Chen M,Xu Y,Paul Morgan B,Mack M,Xu H,Nicholson LB,Dick AD

Thu Jan 15 00:00:00 EST 2015

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.

Nature communications

Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Tue Oct 28 00:00:00 EDT 2014

Alveolar progenitor and stem cells in lung development, renewal and cancer.

Nature

Desai TJ,Brownfield DG,Krasnow MA

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Thu Mar 13 00:00:00 EDT 2014

Dedifferentiation of committed epithelial cells into stem cells in vivo.

Nature

Tata PR,Mou H,Pardo-Saganta A,Zhao R,Prabhu M,Law BM,Vinarsky V,Cho JL,Breton S,Sahay A,Medoff BD,Rajagopal J

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Immunofluorescence

Thu Nov 14 00:00:00 EST 2013

Small intestine inflammation in Roquin-mutant and Roquin-deficient mice.

PloS one

Schaefer JS,Montufar-Solis D,Nakra N,Vigneswaran N,Klein JR

Published figure using Ki-67 monoclonal antibody (Product # 13-5698-82) in Flow Cytometry

Tue Sep 03 00:00:00 EDT 2013

Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens.

Journal of immunology (Baltimore, Md. : 1950)

Yammani RD,Haas KM

Mon Apr 01 00:00:00 EDT 2013

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.

Nature immunology

Pang IK,Ichinohe T,Iwasaki A

Fri Mar 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: Antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; unnamed protein product

Gene Aliases: D630048A14Rik; Ki-67; Ki67; KIA; MIB-; MIB-1; MKI67; PPP1R105

UniProt ID: (Human) P46013, (Mouse) E9PVX6

Entrez Gene ID: (Dog) 100686578, (Human) 4288, (Cynomolgus monkey) 102135895, (Rat) 291234, (Mouse) 17345

Function(s)

DNA metabolic process meiotic nuclear division cell proliferation response to organic cyclic compound hyaluronan metabolic process organ regeneration cellular response to heat hepatocyte proliferation cholangiocyte proliferation

Process(es)

protein binding ATP binding protein C-terminus binding poly(A) RNA binding molecular_function