The KIR2 subunit family includes 2.1, 2.2, 2.3 and 2.4. Unlike G protein-coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2.1 colocalizes with KIR5.1 in the proximal tubule. KIR2.1, 2.2 and 2.3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2.2 by protein kinase A inhibits the associates with SAP97.
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Protein Aliases: Cardiac inward rectifier potassium channel; HHBIRK1; HHIRK1; HIRK 1; hIRK1; Inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; Inward rectifier potassium channel 2; IRK-1; IRK1; KCNJ2; LQT7; Potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium inwardly rectifying channel J2; potassium inwardly-rectifying channel, subfamily J, member 2; RBL-IRK1; SQT3
Gene Aliases: ATFB9; EGK_08925; HHBIRK1; HHIRK1; IRK1; Kcnf1; KCNJ2; KIR2.1; LQT7; SQT3