This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
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Protein Aliases: ATP-sensitive inward rectifier potassium channel 12; atrium potassium channel IRK; Inward rectifier K(+) channel Kir2.2; Inward rectifier K(+) channel Kir2.2v; inward rectifier K(+) channel Kir2.6; Inward rectifier K(+) channel Kir22; Inward rectifier K(+) channel Kir22v; inwardly rectifying subfamily J member 12; inwardly-rectifying potassium channel Kir2.2; IRK-2; IRK2; KCNJ12; KCNJN1; Potassium channel; Potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium inwardly-rectifying channel J12; potassium inwardly-rectifying channel, subfamily J, inhibitor 1; potassium inwardly-rectifying channel, subfamily J, member 12
Gene Aliases: BOS_18984; hIRK; hIRK1; hkir2.2x; IRK; IRK-2; IRK2; KCNJ12; kcnj12x; KCNJN1; Kir2.1; KIR2.2; Kir2.2v; MB-IRK2