Immunogen sequence: NGRCNVQHGN LGSETSRYLS DLFTTLVDLK WRWNLFIFIL TYTVAWLFMA SMWWVIAYTR GDLNKAHVGN YTPCVANVYN FPSAFLFFIE TEATIGYGYR Y; Positive Samples: Mouse brain, Rat brain; Cellular Location: Membrane, Multi-pass membrane protein
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
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Protein Aliases: G protein-activated inward rectifier potassium channel 1; GIRK-1; GIRK1; Inward rectifier K(+) channel Kir3.1; inward rectifier K+ channel KIR3.1; KGA; KGB1; potassium channel inwarding rectifying channel subfamily J member 3; potassium channel subunit Kir3.1 type 3 delta; Potassium channel, inwardly rectifying subfamily J member 3; potassium channel, inwardly rectifying subfamily J, member 3; potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e; potassium inwardly-rectifying channel, subfamily J, member 3
Gene Aliases: GIRK-1; GIRK1; Kcnf3; KCNJ3; KGA; KIR3.1