Product References
Sirt3 enhances glioma cell viability by stabilizing Ku70-BAX interaction.
OncoTargets and therapy
Luo K,Huang W,Tang S
MA5-13110 was used in Western Blotting to study the expression and function of sirtuin 3 in glioma.
Wed Mar 30 00:00:00 EDT 2022
Sirt3 enhances glioma cell viability by stabilizing Ku70-BAX interaction.
OncoTargets and therapy
Luo K,Huang W,Tang S
MA5-13110 was used in Western Blotting to study the expression and function of sirtuin 3 in glioma.
Wed Mar 30 00:00:00 EDT 2022
PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading.
eLife
Rona G,Roberti D,Yin Y,Pagan JK,Homer H,Sassani E,Zeke A,Busino L,Rothenberg E,Pagano M
MA5-13110 was used in Immunocytochemistry-immunoflourescence to study the mechanism of FBXL10-RNF68-RNF2 ubiquitin ligase complex recruitment to DNA damage.
Mon Jul 09 00:00:00 EDT 2018
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
Nature communications
Feng W,Kawauchi D,Körkel-Qu H,Deng H,Serger E,Sieber L,Lieberman JA,Jimeno-González S,Lambo S,Hanna BS,Harim Y,Jansen M,Neuerburg A,Friesen O,Zuckermann M,Rajendran V,Gronych J,Ayrault O,Korshunov A,Jones DT,Kool M,Northcott PA,Lichter P,Cortés-Ledesma F,Pfister SM,Liu HK
MA513110 was used in western blot to explore the role of chromodomain helicase DNA-binding protein 7 in CHARGE syndrome
Mon Mar 20 00:00:00 EDT 2017
Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer.
Nature structural & molecular biology
Zhang Y,He Q,Hu Z,Feng Y,Fan L,Tang Z,Yuan J,Shan W,Li C,Hu X,Tanyi JL,Fan Y,Huang Q,Montone K,Dang CV,Zhang L
Published figure using Ku70 monoclonal antibody (Product # MA5-13110) in Immunoprecipitation
Wed Jun 01 00:00:00 EDT 2016
Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer.
Nature structural & molecular biology
Zhang Y,He Q,Hu Z,Feng Y,Fan L,Tang Z,Yuan J,Shan W,Li C,Hu X,Tanyi JL,Fan Y,Huang Q,Montone K,Dang CV,Zhang L
Published figure using Ku70 monoclonal antibody (Product # MA5-13110) in Immunoprecipitation
Wed Jun 01 00:00:00 EDT 2016
LRBA deficiency with autoimmunity and early onset chronic erosive polyarthritis.
Clinical immunology (Orlando, Fla.)
Lévy E,Stolzenberg MC,Bruneau J,Breton S,Neven B,Sauvion S,Zarhrate M,Nitschké P,Fischer A,Magérus-Chatinet A,Quartier P,Rieux-Laucat F
MA5-13110 was used in western blot to study correlation between early onset chronic erosive polyarthritis and LRBA deficiency with autoimmunity
Fri Jul 01 00:00:00 EDT 2016
Atypical Manifestation of LPS-Responsive Beige-Like Anchor Deficiency Syndrome as an Autoimmune Endocrine Disorder without Enteropathy and Immunodeficiency.
Frontiers in pediatrics
Bakhtiar S,Ruemmele F,Charbit-Henrion F,Lévy E,Rieux-Laucat F,Cerf-Bensussan N,Bader P,Paetow U
Published figure using Ku70 monoclonal antibody (Product # MA5-13110) in Western Blot
Thu Sep 29 00:00:00 EDT 2016
The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells.
Cancer medicine
Hirakawa H,Fujisawa H,Masaoka A,Noguchi M,Hirayama R,Takahashi M,Fujimori A,Okayasu R
MA5-13110 was used in western blot to analyze effective tumor control in human lung cancer cells by the combination of heavy-ion irradiation and Hsp90 inhibitor 17AAG
Sun Mar 01 00:00:00 EST 2015
Dynamic changes in subcellular localization of cattle XLF during cell cycle, and focus formation of cattle XLF at DNA damage sites immediately after irradiation.
The Journal of veterinary medical science
Koike M,Yutoku Y,Koike A
MA5-13110 was used in western blot to characterize cattle XLF for focus formation at DNA damage sites after irradiation and dynamic changes in subcellular localization during cell cycle
Tue Sep 01 00:00:00 EDT 2015
A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines.
Oncotarget
Bouley J,Saad L,Grall R,Schellenbauer A,Biard D,Paget V,Morel-Altmeyer S,Guipaud O,Chambon C,Salles B,Maloum K,Merle-Béral H,Chevillard S,Delic J
MA5-13110 was used in immunoprecipitation and western blot to investigate the role of phospho-Ku70 in DNA repair
Tue Sep 29 00:00:00 EDT 2015
Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases.
Cell death & disease
Ngo J,Matsuyama M,Kim C,Poventud-Fuentes I,Bates A,Siedlak SL,Lee HG,Doughman YQ,Watanabe M,Liner A,Hoit B,Voelkel N,Gerson S,Hasty P,Matsuyama S
MA5-13110 was used in western blot to test if Bax-mediated apoptosis contributes to the premature death of ku70 knockout mice
Thu Mar 26 00:00:00 EDT 2015
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.
Nature communications
He S,Zhao Z,Yang Y,O'Connell D,Zhang X,Oh S,Ma B,Lee JH,Zhang T,Varghese B,Yip J,Dolatshahi Pirooz S,Li M,Zhang Y,Li GM,Ellen Martin S,Machida K,Liang C
MA5-13110 was used in immunoprecipitation to study the role of autophagy factors in cancer progression and treatment response
Mon Aug 03 00:00:00 EDT 2015
C/EBPβ (CCAAT/enhancer-binding protein β) mediates progesterone production through transcriptional regulation in co-operation with SF-1 (steroidogenic factor-1).
The Biochemical journal
Mizutani T,Ju Y,Imamichi Y,Osaki T,Yazawa T,Kawabe S,Ishikane S,Matsumura T,Kanno M,Kamiki Y,Kimura K,Minamino N,Miyamoto K
MA5-13110 was used in western blot to study the role of cooperation between C/EBPbeta and steroidogenic factor-1 in the regulation of progesterone synthesis
Sun Jun 15 00:00:00 EDT 2014
DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1.
Nucleic acids research
Calkins AS,Iglehart JD,Lazaro JB
MA5-13110 was used in immunocytochemistry and western blot to study the role of DNA-PK and PARP in the mechanism by which DNA damage inhibits the synthesis of rRNA
Thu Aug 01 00:00:00 EDT 2013
A noncatalytic function of the ligation complex during nonhomologous end joining.
The Journal of cell biology
Cottarel J,Frit P,Bombarde O,Salles B,Négrel A,Bernard S,Jeggo PA,Lieber MR,Modesti M,Calsou P
MA5-13110 was used in western blot to study the significance of non-catalytic functions of DNA Ligase IV in the ligation complex during non-homologous end-joining
Mon Jan 21 00:00:00 EST 2013
Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability.
Human molecular genetics
Le Guen T,Jullien L,Touzot F,Schertzer M,Gaillard L,Perderiset M,Carpentier W,Nitschke P,Picard C,Couillault G,Soulier J,Fischer A,Callebaut I,Jabado N,Londono-Vallejo A,de Villartay JP,Revy P
MA5-13110 was used in immunocytochemistry and western blot to study the role of RTEL1 deficiency as a novel cause of Hoyerdaal-Hreidarssen syndrome
Thu Aug 15 00:00:00 EDT 2013
Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage.
PloS one
Cousin W,Ho ML,Desai R,Tham A,Chen RY,Kung S,Elabd C,Conboy IM
MA5-13110 was used in western blot to explore the effects of aging on the intrinsic properties of satellite cells
Mon Dec 30 00:00:00 EST 2013
Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1.
Genes & cancer
Datta J,Ghoshal K,Motiwala T,Jacob ST
MA5-13110 was used in western blot to study the role of PKCdelta in the decitabine-induced degradation of the maintenance methyltransferase DNMT1
Sun Jan 01 00:00:00 EST 2012
Modification of the DNA damage response by therapeutic CDK4/6 inhibition.
The Journal of biological chemistry
Dean JL,McClendon AK,Knudsen ES
MA5-13110 was used in Western Blotting to investigate how repression of E2F activity via CDK4/6 inhibition and retinoblastoma activation impacts the response of triple negative breast cancer to frequently used therapeutic agents.
Fri Aug 17 00:00:00 EDT 2012
DNA ends alter the molecular composition and localization of Ku multicomponent complexes.
Molecular & cellular proteomics : MCP
Adelmant G,Calkins AS,Garg BK,Card JD,Askenazi M,Miron A,Sobhian B,Zhang Y,Nakatani Y,Silver PA,Iglehart JD,Marto JA,Lazaro JB
MA5-13110 was used in Immunocytochemistry to define the composition of Ku multicomponent complexes, and demonstrate that they are dramatically altered in response to UV radiation.
Wed Aug 01 00:00:00 EDT 2012
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
Molecular cancer
Sand-Dejmek J,Adelmant G,Sobhian B,Calkins AS,Marto J,Iglehart DJ,Lazaro JB
MA5-13110 was used in western blot to identify the effect of DNA-dependent protein kinase on cisplatin treatment
Thu Jun 16 00:00:00 EDT 2011
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.
PloS one
Martinez-Marignac VL,Rodrigue A,Davidson D,Couillard M,Al-Moustafa AE,Abramovitz M,Foulkes WD,Masson JY,Aloyz R
MA5-13110 was used in western blot to test if over-expression of DNA repair genes enhances the invasive behavior of tumor cells
Mon Jan 24 00:00:00 EST 2011
Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells.
Blood
Brugat T,Nguyen-Khac F,Grelier A,Merle-Béral H,Delic J
MA5-13110 was used in ChIP assay to investigate the effect of telomere dysfunction-mediated chromosomal aberration on the prognosis of chronic lymphocytic leukemia patients
Thu Jul 15 00:00:00 EDT 2010
DNA damage-induced translocation of S100A11 into the nucleus regulates cell proliferation.
BMC cell biology
Gorsler T,Murzik U,Ulbricht T,Hentschel J,Hemmerich P,Melle C
MA5-13110 was used in Western Blotting to analyse the underlying mechanism of S100A11 subcellular trafficking in response to DNA damage.
Fri Dec 17 00:00:00 EST 2010
Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance.
Nucleic acids research
Li S,Kuhne WW,Kulharya A,Hudson FZ,Ha K,Cao Z,Dynan WS
MA5-13110 was used in western blot to investigate the role of p54(nrb) in DNA double-strand break repair in vivo
Sun Nov 01 00:00:00 EDT 2009
Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
Biochemical and biophysical research communications
Ohno M,Kunimoto M,Nishizuka M,Osada S,Imagawa M
MA5-13110 was used in western blot to investigate the effect of Ku proteins on farnesoid X receptor-mediated gene expression
Fri Dec 18 00:00:00 EST 2009
Molecular analysis of Ku redox regulation.
BMC molecular biology
Bennett SM,Neher TM,Shatilla A,Turchi JJ
MA5-13110 was used in western blot to investigate the regulatory effect of redox conditions on the function of Ku
Fri Aug 28 00:00:00 EDT 2009
Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo.
Cancer science
Yu D,Sekine E,Fujimori A,Ochiya T,Okayasu R
MA5-13110 was used in western blot to investigate the effect of BRCA2 on the radio-sensitization of human tumor cells
Tue Apr 01 00:00:00 EDT 2008
Rad54B targeting to DNA double-strand break repair sites requires complex formation with S100A11.
Molecular biology of the cell
Murzik U,Hemmerich P,Weidtkamp-Peters S,Ulbricht T,Bussen W,Hentschel J,von Eggeling F,Melle C
MA5-13110 was used in immunocytochemistry to examine the interaction between Rad54B and S100A11 and its role in DNA damage repair
Tue Jul 01 00:00:00 EDT 2008
Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions.
Cancer research
He F,Li L,Kim D,Wen B,Deng X,Gutin PH,Ling CC,Li GC
MA5-13110 was used in Western Blotting to examine the use of a radio-gene therapy paradigm to sensitise cells to ionising radiation.
Mon Jan 15 00:00:00 EST 2007
Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing.
Molecular cancer research : MCR
Biard DS,Despras E,Sarasin A,Angulo JF
MA5-13110 was used in western blot to investigate a novel method of stably expressing small interfering RNA to generate human disease models
Thu Sep 01 00:00:00 EDT 2005
Interaction of radiation- and bleomycin-induced lesions and influence of glutathione level on the interaction.
Mutagenesis
Dutta A,Chakraborty A,Saha A,Ray S,Chatterjee A
MA5-13110 was used in western blot to study the effect of the glutathione levels on the interaction of radiation- and bleomycin-induced lesions
Thu Sep 01 00:00:00 EDT 2005
DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.
The Journal of biological chemistry
Drouet J,Delteil C,Lefrançois J,Concannon P,Salles B,Calsou P
MA5-13110 was used in western blot to study the mobilization of DNA-dependent protein kinase and XRCC4-ligase IV in response to DNA double strand breaks
Fri Feb 25 00:00:00 EST 2005
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
The Journal of biological chemistry
Audebert M,Salles B,Calsou P
MA5-13110 was used in western blot to study an alternative pathway for the repair of DNA double-strand breaks that involves poly(ADP-ribose) polymerase-1 and a XRCC1-DNA ligase III complex
Fri Dec 31 00:00:00 EST 2004
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Journal of molecular biology
Calsou P,Delteil C,Frit P,Drouet J,Salles B
MA5-13110 was used in western blot to investigate the relationship and assembly of specific proteins during DNA repair process
Fri Feb 07 00:00:00 EST 2003
Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription.
Gene
Bertinato J,Tomlinson JJ,Schild-Poulter C,Haché RJ
MA5-13110 was used in western blot to study the potential role of the Ku antigen within the RNA polymerase II holoenzyme
Thu Jan 02 00:00:00 EST 2003
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
The Journal of biological chemistry
Udayakumar D,Bladen CL,Hudson FZ,Dynan WS
MA5-13110 was used in western blot to study two biochemically distinct pathways of non-homologous end joining that are differentially regulated by DNA-PK
Fri Oct 24 00:00:00 EDT 2003
The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit.
Oncogene
Ader I,Muller C,Bonnet J,Favre G,Cohen-Jonathan E,Salles B,Toulas C
MA5-13110 was used in Western Blotting to characterise a novel mechanism of control of DNA repair and radioresistance in human tumour cells.
Thu Sep 19 00:00:00 EDT 2002
Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress.
The Journal of biological chemistry
Ayene IS,Stamato TD,Mauldin SK,Biaglow JE,Tuttle SW,Jenkins SF,Koch CJ
MA5-13110 was used in Western Blotting to discover a new layer of DNA damage repair, that of the functional maintenance of repair proteins themselves.
Fri Mar 22 00:00:00 EST 2002
Regulation and localization of the Bloom syndrome protein in response to DNA damage.
The Journal of cell biology
Bischof O,Kim SH,Irving J,Beresten S,Ellis NA,Campisi J
MA5-13110 was used in Western Blotting to suggest that BLM is part of a dynamic nuclear matrix-based complex that requires PML and functions during G2 in undamaged cells and recombinational repair after DNA damage.
Mon Apr 16 00:00:00 EDT 2001
Expression and chromosome location of hamster Ku70 and Ku80.
Cytogenetics and cell genetics
Koike M,Kuroiwa A,Koike A,Shiomi T,Matsuda Y
MA5-13110 was used in western blot to study the chromosomal location of hamster Ku70 and Ku80 and the effect of ionizing radiation on their expression levels
Thu Sep 06 00:00:00 EDT 2001
Ku entry into DNA inhibits inward DNA transactions in vitro.
The Journal of biological chemistry
Frit P,Li RY,Arzel D,Salles B,Calsou P
MA5-13110 was used in western blot to study the effect of Ku entry into DNA on local DNA processes and the regulatory role of DNA-dependent protein kinase
Fri Nov 17 00:00:00 EST 2000
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
The Journal of biological chemistry
Galande S,Kohwi-Shigematsu T
MA5-13110 was used in western blot to study the binding of poly(ADP-ribose) polymerase and Ku autoantigen to matrix attachment sequences
Fri Jul 16 00:00:00 EDT 1999