|Tested species reactivity||Bovine, Dog, Human, Mouse, Pig, Rat, Xenopus, Zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide made to rat Kv1.2 (within residues 50-100), which is identical in all members of the Kv1 family.|
|Purification||Antigen affinity chromatography|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: HEK293 cell lysate.
Kv1 is a subfamily (also called the Shaker family) of voltage-gated potassium channels containing at least seven members. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kv1 subfamily may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.