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Antibodies Inc
Kv7.2/KCNQ2 K+ channel Monoclonal Antibody (N26A/23)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
73-079
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N26A/23
Immunogen
Fusion protein amino acids 1-59 (cytoplasmic N-terminus) of human KCNQ2 (accession number O43526) produced recombinantly in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KQT like 2; KQT-like 2; KVEBN1; neuroblastoma-specific potassium channel subunit alpha KvLQT2; potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; potassium channel, voltage-gated KQT-like subfamily Q, member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; unnamed protein product; voltage-gated potassium channel subunit Kv7.2
Gene Aliases: BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11; KQT2; KV7.2; Nmf134
UniProt ID: (Human) O43526, (Rat) O88943, (Mouse) Q9Z351
Entrez Gene ID: (Human) 3785, (Rat) 170848, (Mouse) 16536
action potential
protein phosphorylation
protein import into nucleus
ion transport
potassium ion transport
exocytosis
endocytosis
brain development
sensory perception of sound
learning
memory
grooming behavior
determination of adult lifespan
response to temperature stimulus
response to xenobiotic stimulus
response to mechanical stimulus
gene expression
response to auditory stimulus
protein transport
neuron remodeling
transmission of nerve impulse
neuronal action potential
dentate gyrus development
nerve development
hippocampus development
establishment of cell polarity
neuron differentiation
ion transmembrane transport
social behavior
exploration behavior
sodium ion transmembrane transport
psychomotor behavior
regulation of membrane potential
regulation of synaptic plasticity
cognition
neuron apoptotic process
mitochondrial depolarization
transmembrane transport
motor behavior
cellular response to calcium ion
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
apoptosome assembly
hippocampal pyramidal neuron differentiation
excitatory chemical synaptic transmission
inhibitory chemical synaptic transmission
action potential initiation
regulation of action potential firing threshold
substantia propria of cornea development
chemical synaptic transmission
nervous system development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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