The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine and Orangutan
The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; p27kip1 releasing factor from RhoA; p27Kip1-releasing factor from RhoA; p27RF Rho; p27RF-Rho; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; RhoA activator C11orf59
Gene Aliases: C11orf59; LAMTOR1; p18; p27RF-Rho; PDRO; PP7157; Ragulator1
UniProt ID: (Human) Q6IAA8
Entrez Gene ID: (Human) 55004