MA1-074 detects lamin associated polypeptide (LAP) 1A, 1B and 1C from rat, human, and mouse samples. This antibody does not cross-react with LAP 2.
MA1-074 has been successfully used in Western blot, immunofluorescence, immunohistochemistry, and immunoprecipitation procedures. By Western blot, this antibody detects 3 distinct proteins of molecular weights ~65, ~56 and ~ 51 kDa representing LAP 1A, 1B, and 1C, respectively in rat liver nuclear envelope fractions. Immunofluorescence staining of LAP 1 in rat liver with MA1-074 results in exclusive labeling of the nuclear periphery and exhibits co-localization with lamin staining.
The MA1-074 immunogen is pore complex-lamina fraction isolated from rat liver nuclear envelopes.
Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Lamin-associated protein 1B; Lamina-associated polypeptide 1B; Lamina-associated polypeptide 1C; LAP1B; LAP1C; torsin A interacting protein 1; Torsin-1A-interacting protein 1
Gene Aliases: LAP1; LAP1B; Lap1c; TOR1AIP1