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LARGE Antibody (MA5-28611) in Flow
Separation of Hek293 cells transfected with LARGE1 vector and stained using anti-LARGE1 (LARGE-02) purified Monoclonal antibody (Product # MA5-28611), concentration in sample 15 µg/mL (GAM APC, red-filled) from Hek293 cells transfected with LARGE1 and unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (intracellular staining).
Product Details
MA5-28611
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
LARGE-02
Immunogen
Human LARGE1 (amino acids 35-142)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745570
Product Specific Information
This antibody recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Cross reactivity with LARGE2 was not determined.
Target Information
The LARGE gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; Glycosyltransferase-like protein; LARGE xylosyl- and glucuronyltransferase 1; like-acetylglucosaminyltransferase; like-glycosyltransferase; Xylosyl- and glucuronyltransferase LARGE1
Gene Aliases: KIAA0609; LARGE; LARGE1; MDC1D; MDDGA6; MDDGB6
UniProt ID: (Human) O95461
Entrez Gene ID: (Human) 9215
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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