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Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: LAS1-like, ribosome biogenesis factor; Protein LAS1 homolog; Ribosomal biogenesis protein LAS1L
Gene Aliases: 1810030A06Rik; 5830482G23Rik; dJ475B7.2; Las1-like; LAS1L; MSTP060