Perlecan is an extracellular matrix proteoglycan. It has a large core protein of 400-450 kDa and is often produced with heparan sulfate side chains. Perlecan is found in basement membranes where it contributes to the permeability characteristics, serves as a substrate for vascular cells and binds growth factors involved in vascular remodelling.
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Protein Aliases: [phosphatase 2A protein]-leucine-carboxy methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; Leucine carboxyl methyltransferase 1; protein phosphatase methyltransferase 1; Protein-leucine O-methyltransferase
Gene Aliases: CGI-68; LCMT; LCMT1; PPMT1
UniProt ID: (Human) Q9UIC8
Entrez Gene ID: (Human) 51451
Molecular Function: methyltransferase