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Proteintech
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Immunogen sequence: VFPASVVSSE GQVPNLKRYG HASVFLSPDV ILSAGGFGEQ EGRHCRVSQF HLLSRDCDSE WKGSQIGSCG TGVQWDGRLY HTMTRLSESR VLVLGGRLSP VSPALGVLQL HFFKSEDNNT EDLKVTITKA GRKDDSTLCC WRHSTTEVSC QNQEYLFVYG GRSVVEPVLS DWHFLHVGTM AWVRIPVEGE VPEARHSHSA CTWQGGALIA GGLGASEEPL NSVLFLRPIS CGFLWESVDI QPPITPRYSH TAHVLNGKLL LVGGIWIHSS SFPGVTVINL TTGLSSEYQI DTTYVPWPLM LHNHTSILLP EEQQLLLLGG GGNCFSFGTY FNPHTVTLDL SSLSAGQ
TYW4 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW4 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Leucine carboxyl methyltransferase 2; p21WAF1/CIP1 promoter-interacting protein; tRNA wybutosine-synthesizing protein 4; tRNA yW-synthesizing protein 4; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase; tRNA-Wybutosine-synthesizing protein 4; tRNA-yW synthesizing protein 4
Gene Aliases: KIAA0547; LCMT2; PPM2; TYW4
UniProt ID: (Human) O60294
Entrez Gene ID: (Human) 9836
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