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Product Details
H00010637-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2E10
Immunogen
LEFTY1 (AAH27883, 1 a.a. approximately 366 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MQPLWLCWAL WVLPLASPGA ALAGEQLLGS LLRQLQLKEV PTLDRADMEE LVIPTHVRAQ YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSLRS ARARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLGDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV PRRLQP
Target Information
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Left-right determination factor 1; Left-right determination factor B; left-right determination, factor B; Protein lefty-1; Protein lefty-B
Gene Aliases: LEFTB; LEFTY1; LEFTYB; UNQ278/PRO317
UniProt ID: (Human) O75610
Entrez Gene ID: (Human) 10637
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transforming growth factor beta receptor signaling pathway
determination of left/right symmetry
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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