Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Growth suppressor 1; leprecan; Leprecan-1; leucine proline-enriched proteoglycan (leprecan) 1; Leucine- and proline-enriched proteoglycan 1; procollagen-proline 3-dioxygenase; Prolyl 3-hydroxylase 1
Gene Aliases: GROS1; LEPRE1; OI8; P3H1; PSEC0109
UniProt ID: (Human) Q32P28
Entrez Gene ID: (Human) 64175
Molecular Function: extracellular matrix glycoprotein