Keep as concentrated solution.
Positive Control: NT2D1, human ESC, LIN28 transfected HeLa lysates, mouse placenta.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCHC domain containing 1 antibody; CSDD1 antibody; FLJ12457 antibody; LIN-28 antibody; lin-28 homolog A (C. elegans) antibody; Lin-28A; LIN28 antibody; LIN28A antibody; Protein lin-28 homolog A; protein lin-28 homolog A antibody; RNA-binding protein LIN-28; RNA-binding protein LIN-28 antibody; testis expressed gene 17; Testis-expressed protein 17; ZCCHC1 antibody; zinc finger; Zinc finger CCHC domain-containing protein 1; zinc finger CCHC domain-containing protein 1 antibody; zinc finger, CCHC domain containing 1
Gene Aliases: AL024421; CSDD1; ENSMUSG00000070700; Gm10299; LIN-28; lin-28A; LIN28; LIN28A; Tex17; ZCCHC1
Molecular Function: DNA binding protein