Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hLin7B; hVeli2; lin-7 homolog B; Lin-7B; MALS-2; Mammalian lin-seven protein 2; Protein lin-7 homolog B; Veli-2; Vertebrate lin-7 homolog 2
Gene Aliases: LIN-7B; LIN7B; MALS-2; MALS2; UNQ3116/PRO10200; VELI2
UniProt ID: (Human) Q9HAP6
Entrez Gene ID: (Human) 64130
Molecular Function: cell junction protein