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LIPG (Lipase G, Endohelial type) is an endothelial lipase which is a novel member of the lipoprotein lipase gene family. LIPG is synthesized by endothelial cells and functions at the site of synthesis. LIPG most likely plays a physiological role in modulating lipoprotein metabolism. Overexpressed LIPG has been shown to reduce HDL cholesterol levels, whereas an LIPG deficiency appears to be effective in elevating HDL cholesterol levels in animals. LIPG has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. Also, LIPG is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. LIPG is a carboxyl esterase that hydrolyzes high density lipoproteins, emulsifies triglycerides, is essential for the efficient digestion of dietary fats and can bind to heparin.
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Protein Aliases: EDL; Endothelial cell-derived lipase; Endothelial lipase; lipase, endothelial; lipoprotein lipase H; Phospholipase A1
Gene Aliases: EDL; EL; LIPG; PRO719; UNQ387/PRO719
UniProt ID: (Human) Q9Y5X9
Entrez Gene ID: (Human) 9388
Molecular Function: lipase